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10.26355/eurrev_202004_21041 http://scihub22266oqcxt.onion/10.26355/eurrev_202004_21041 32373995!ä!32373995 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Rev+Med+Pharmacol+Sci 2020 ; 24 (8): 4558-4564 Nephropedia Template TP {{tp|p=32373995|t=2020. Bioinformatic analysis indicates that SARS-CoV-2 is unrelated to known artificial coronaviruses |pdf=|usr=}}{{32373995}} gab.com Text Bioinformatic analysis indicates that SARS-CoV-2 is unrelated to known artificial coronaviruses JO: Eur Rev Med Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32373995 #FOAvip OBJECTIVE: SARS-CoV-2 is responsible for the present coronavirus pandemic and some suggestions were made about its possible artificial origin. We, therefore, compared SARS-CoV-2 with such known viruses that were prepared in the laboratory and other relevant natural strains to estimate their genetic relatedness. MATERIALS AND METHODS: BLAST and clustalW were used to identify and align viral sequences of SARS-CoV-2 to other animal coronaviruses (human, bat, mouse, pangolin) and related artificial constructs. Phylogenetics trees were then prepared using iTOL. RESULTS: Our study supports the notion that known artificial coronaviruses, including the chimeric SL-SHC014-MA15 synthesized in 2015, differ too much from SARS-CoV-2 to hypothesize an artificial origin of the latter. On the contrary, our data support the natural origin of the COVID-19 virus, likely derived from bats, possibly transferred to pangolins, before spreading to man. CONCLUSIONS: Speculations about the artificial origin of SARS-CoV-2 are most likely unfounded. On the contrary, when carefully handled, engineered organisms provide a unique opportunity to study biological systems in a controlled fashion. Biotechnology is a powerful tool to advance medical research and should not be abandoned because of irrational fears. Twit Text FOAVip Bioinformatic analysis indicates that SARS-CoV-2 is unrelated to known artificial coronaviruses ????Eur Rev Med Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32373995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32373995 #FOAvip English Wikipedia <ref>{{Cite pmid|32373995}}</ref> Bioinformatic analysis indicates that SARS-CoV-2 is unrelated to known artificial coronaviruses #MMPMID32373995 Dallavilla T; Bertelli M; Morresi A; Bushati V; Stuppia L; Beccari T; Chiurazzi P; Marceddu G Eur Rev Med Pharmacol Sci 2020[Apr]; 24 (8): 4558-4564 PMID32373995show ga OBJECTIVE: SARS-CoV-2 is responsible for the present coronavirus pandemic and some suggestions were made about its possible artificial origin. We, therefore, compared SARS-CoV-2 with such known viruses that were prepared in the laboratory and other relevant natural strains to estimate their genetic relatedness. MATERIALS AND METHODS: BLAST and clustalW were used to identify and align viral sequences of SARS-CoV-2 to other animal coronaviruses (human, bat, mouse, pangolin) and related artificial constructs. Phylogenetics trees were then prepared using iTOL. RESULTS: Our study supports the notion that known artificial coronaviruses, including the chimeric SL-SHC014-MA15 synthesized in 2015, differ too much from SARS-CoV-2 to hypothesize an artificial origin of the latter. On the contrary, our data support the natural origin of the COVID-19 virus, likely derived from bats, possibly transferred to pangolins, before spreading to man. CONCLUSIONS: Speculations about the artificial origin of SARS-CoV-2 are most likely unfounded. On the contrary, when carefully handled, engineered organisms provide a unique opportunity to study biological systems in a controlled fashion. Biotechnology is a powerful tool to advance medical research and should not be abandoned because of irrational fears. |*Computational Biology[MESH] |*Phylogeny[MESH] |*Whole Genome Sequencing[MESH] |Animals[MESH] |Betacoronavirus/*classification[MESH] |COVID-19[MESH] |Chiroptera/virology[MESH] |Coronavirus Infections[MESH] |Humans[MESH] |Mice[MESH] |Organisms, Genetically Modified[MESH] |Pandemics[MESH] |Pneumonia, Viral[MESH] |RNA, Viral/analysis[MESH] |SARS-CoV-2[MESH]Bioinformatic analysis indicates that SARS-CoV-2 is unrelated to known(epmc).pdf DeepDyve Pubget Overpricing