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10.1523/JNEUROSCI.2858-19.2020 http://scihub22266oqcxt.onion/10.1523/JNEUROSCI.2858-19.2020 32371602!7252482!32371602     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32371602&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Neurosci 2020 ; 40 (22): 4297-4308 Nephropedia Template TP {{tp|p=32371602|t=2020. Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study |pdf=|usr=}}{{32371602}} gab.com Text Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study JO: J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=32371602 #FOAvip Neuropathic pain is an intractable medical condition with few or no options for effective treatment. Emerging evidence shows a strong structure-function relationship between dendritic spine dysgenesis and the presence of neuropathic pain. Postmortem tissue analyses can only imply dynamic structural changes associated with injury-induced pain. Here, we profiled the in vivo dynamics of dendritic spines over time on the same superficial dorsal horn (lamina II) neurons before and after peripheral nerve injury-induced pain. We used a two-photon, whole-animal imaging paradigm that permitted repeat imaging of the same dendritic branches of these neurons in C57/Bl6 Thy1-YFP male mice. Our study demonstrates, for the first time, the ongoing, steady-state changes in dendritic spine dynamics in the dorsal horn associated with peripheral nerve injury and pain. Ultimately, the relationship between altered dendritic spine dynamics and neuropathic pain may serve as a structure-based opportunity to investigate mechanisms of pain following injury and disease.SIGNIFICANCE STATEMENT This work is important because it demonstrates for the first time: (1) the powerful utility of intravital study of dendritic spine dynamics in the superficial dorsal horn; (2) that nerve injury-induced pain triggers changes in dendritic spine steady-state behavior in the spinal cord dorsal horn; and (3) this work opens the door to further investigations in vivo of spinal cord dendritic spine dynamics in the context of injury and disease. Twit Text FOAVip Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study ????J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=32371602 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32371602 #FOAvip English Wikipedia <ref>{{Cite pmid|32371602}}</ref> Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital Structural Study #MMPMID32371602 Benson CA; Fenrich KK; Olson KL; Patwa S; Bangalore L; Waxman SG; Tan AM J Neurosci 2020[May]; 40 (22): 4297-4308 PMID32371602show ga Neuropathic pain is an intractable medical condition with few or no options for effective treatment. Emerging evidence shows a strong structure-function relationship between dendritic spine dysgenesis and the presence of neuropathic pain. Postmortem tissue analyses can only imply dynamic structural changes associated with injury-induced pain. Here, we profiled the in vivo dynamics of dendritic spines over time on the same superficial dorsal horn (lamina II) neurons before and after peripheral nerve injury-induced pain. We used a two-photon, whole-animal imaging paradigm that permitted repeat imaging of the same dendritic branches of these neurons in C57/Bl6 Thy1-YFP male mice. Our study demonstrates, for the first time, the ongoing, steady-state changes in dendritic spine dynamics in the dorsal horn associated with peripheral nerve injury and pain. Ultimately, the relationship between altered dendritic spine dynamics and neuropathic pain may serve as a structure-based opportunity to investigate mechanisms of pain following injury and disease.SIGNIFICANCE STATEMENT This work is important because it demonstrates for the first time: (1) the powerful utility of intravital study of dendritic spine dynamics in the superficial dorsal horn; (2) that nerve injury-induced pain triggers changes in dendritic spine steady-state behavior in the spinal cord dorsal horn; and (3) this work opens the door to further investigations in vivo of spinal cord dendritic spine dynamics in the context of injury and disease. |Animals[MESH] |Dendritic Spines/*pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Microscopy, Fluorescence, Multiphoton[MESH] |Peripheral Nerve Injuries/*pathology/physiopathology[MESH]Dendritic Spine Dynamics after Peripheral Nerve Injury: An Intravital (epmc).pdf DeepDyve Pubget Overpricing