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10.1080/23744235.2020.1759817

http://scihub22266oqcxt.onion/10.1080/23744235.2020.1759817
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32370577!7212540!32370577
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suck abstract from ncbi


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pmid32370577      Infect+Dis+(Lond) 2020 ; 52 (7): 498-505
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  • Risk factors for disease progression in hospitalized patients with COVID-19: a retrospective cohort study #MMPMID32370577
  • Hou W; Zhang W; Jin R; Liang L; Xu B; Hu Z
  • Infect Dis (Lond) 2020[Jul]; 52 (7): 498-505 PMID32370577show ga
  • Background: To investigate the risk factors related to aggravation and clinical outcomes in coronavirus disease 2019 (COVID-19) patients.Methods: We performed a retrospective study on the risk factors for disease progression of cases with COVID-19. Based on the clinical types, the patients were divided into a progression group and an improvement group. Multivariable logistic regression and ROC curve analysis were performed to explore the risk factors for disease progression.Results: A total of 101 patients were included in this study; diseases progression occurred in 17 patients, 84 patients improved, 6 were transferred to intensive care unit (ICU), and 5 died. The mean time to obtain negative nucleic acid results was 12.5 +/- 5.0 days. Multivariate logistic analysis indicated that age (OR, 0.104; p = .002), C-reactive protein (CRP) (OR, 0.093; p < .001) and lymphocyte count (OR, 3.397; p = .022) were risk factors for disease progression. ROC curve analysis revealed that the AUC of age, CRP and lymphocyte count for disease progression were 0.873, 0.911 and 0.817, respectively.Conclusions: Older age increased CRP and decreased lymphocyte count resulted in potential risk factors for COVID-19 progression. This may be helpful in identifying patients whose condition worsens at an early stage.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Beijing/epidemiology[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |C-Reactive Protein/metabolism[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/blood/*pathology/therapy/virology[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Intensive Care Units[MESH]
  • |Logistic Models[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multivariate Analysis[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/blood/*pathology/therapy/virology[MESH]
  • |ROC Curve[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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