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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Metab 2020 ; 31 (6): 1068-1077.e3 Nephropedia Template TP
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Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes #MMPMID32369736
Zhu L; She ZG; Cheng X; Qin JJ; Zhang XJ; Cai J; Lei F; Wang H; Xie J; Wang W; Li H; Zhang P; Song X; Chen X; Xiang M; Zhang C; Bai L; Xiang D; Chen MM; Liu Y; Yan Y; Liu M; Mao W; Zou J; Liu L; Chen G; Luo P; Xiao B; Zhang C; Zhang Z; Lu Z; Wang J; Lu H; Xia X; Wang D; Liao X; Peng G; Ye P; Yang J; Yuan Y; Huang X; Guo J; Zhang BH; Li H
Cell Metab 2020[Jun]; 31 (6): 1068-1077.e3 PMID32369736show ga
Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D.