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10.1111/bph.15092 http://scihub22266oqcxt.onion/10.1111/bph.15092 32368792!7267399!32368792     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32368792.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Pharmacol 2020 ; 177 (14): 3147-3161 Nephropedia Template TP {{tp|p=32368792|t=2020. Potential therapeutic targets and promising drugs for combating SARS-CoV-2 |pdf=|usr=}}{{32368792}} gab.com Text Potential therapeutic targets and promising drugs for combating SARS-CoV-2 JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32368792 #FOAvip As of April 9, 2020, a novel coronavirus (SARS-CoV-2) had caused 89,931 deaths and 1,503,900 confirmed cases worldwide, which indicates an increasingly severe and uncontrollable situation. Initially, little was known about the virus. As research continues, we now know the genome structure, epidemiological and clinical characteristics, and pathogenic mechanisms of SARS-CoV-2. Based on this knowledge, potential targets involved in the processes of virus pathogenesis need to be identified, and the discovery or development of drugs based on these potential targets is the most pressing need. Here, we have summarized the potential therapeutic targets involved in virus pathogenesis and discuss the advances, possibilities, and significance of drugs based on these targets for treating SARS-CoV-2. This review will facilitate the identification of potential targets and provide clues for drug development that can be translated into clinical applications for combating SARS-CoV-2. Twit Text FOAVip Potential therapeutic targets and promising drugs for combating SARS-CoV-2 ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32368792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32368792 #FOAvip English Wikipedia <ref>{{Cite pmid|32368792}}</ref> Potential therapeutic targets and promising drugs for combating SARS-CoV-2 #MMPMID32368792 Zhou H; Fang Y; Xu T; Ni WJ; Shen AZ; Meng XM Br J Pharmacol 2020[Jul]; 177 (14): 3147-3161 PMID32368792show ga As of April 9, 2020, a novel coronavirus (SARS-CoV-2) had caused 89,931 deaths and 1,503,900 confirmed cases worldwide, which indicates an increasingly severe and uncontrollable situation. Initially, little was known about the virus. As research continues, we now know the genome structure, epidemiological and clinical characteristics, and pathogenic mechanisms of SARS-CoV-2. Based on this knowledge, potential targets involved in the processes of virus pathogenesis need to be identified, and the discovery or development of drugs based on these potential targets is the most pressing need. Here, we have summarized the potential therapeutic targets involved in virus pathogenesis and discuss the advances, possibilities, and significance of drugs based on these targets for treating SARS-CoV-2. This review will facilitate the identification of potential targets and provide clues for drug development that can be translated into clinical applications for combating SARS-CoV-2. |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH] |Alanine/analogs & derivatives/therapeutic use[MESH] |Angiotensin II Type 1 Receptor Blockers/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH] |Antiviral Agents/therapeutic use[MESH] |Basigin/metabolism[MESH] |Benzamidines[MESH] |Betacoronavirus/*genetics/metabolism/pathogenicity[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19 Serotherapy[MESH] |COVID-19 Vaccines[MESH] |Coronavirus Infections/complications/*drug therapy/immunology/metabolism/prevention & control/therapy[MESH] |Cytokine Release Syndrome/drug therapy/etiology/immunology[MESH] |Esters[MESH] |Gabexate/analogs & derivatives/therapeutic use[MESH] |Genome, Viral[MESH] |Guanidines/therapeutic use[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Immunosuppressive Agents/therapeutic use[MESH] |Medicine, Chinese Traditional[MESH] |Nucleic Acid Synthesis Inhibitors/therapeutic use[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/complications/*drug therapy/immunology/metabolism[MESH] |Protease Inhibitors/therapeutic use[MESH] |RNA-Dependent RNA Polymerase/metabolism[MESH] |SARS-CoV-2[MESH] |Serine Endopeptidases/metabolism[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH] |Viral Vaccines[MESH] |Virus Internalization[MESH]Potential therapeutic targets and promising drugs for combating SARS-C(epmc).pdf DeepDyve Pubget Overpricing