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10.1002/cbic.202000250

http://scihub22266oqcxt.onion/10.1002/cbic.202000250
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32367615!7687022!32367615
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suck abstract from ncbi


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pmid32367615      Chembiochem 2020 ; 21 (20): 2880-2889
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  • Trends and Innovations in Biosensors for COVID-19 Mass Testing #MMPMID32367615
  • Santiago I
  • Chembiochem 2020[Oct]; 21 (20): 2880-2889 PMID32367615show ga
  • Fast and widespread diagnosis is crucial to fighting against the outbreak of COVID-19. This work surveys the landscape of available and emerging biosensor technologies for COVID-19 testing. Molecular diagnostic assays based on quantitative reverse transcription polymerase chain reaction are used in most clinical laboratories. However, the COVID-19 pandemic has overwhelmed testing capacity and motivated the development of fast point-of-care tests and the adoption of isothermal DNA amplification. Antigenic and serological rapid tests based on lateral-flow immunoassays suffer from low sensitivity. Advanced digital systems enhance performance at the expense of speed and the need for large equipment. Emerging technologies, including CRISPR gene-editing tools, benefit from high sensitivity and specificity of molecular diagnostics and the easy use of lateral-flow assays. DNA sequencing and sample pooling strategies are highlighted to bring out the full capacity of the available biosensor technologies and accelerate mass testing.
  • |*Betacoronavirus[MESH]
  • |Biosensing Techniques/*methods/trends[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/*diagnosis[MESH]
  • |Diagnostic Tests, Routine/*methods/trends[MESH]
  • |Humans[MESH]
  • |Immunoassay/methods[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]


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