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10.1128/AAC.00819-20

http://scihub22266oqcxt.onion/10.1128/AAC.00819-20
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32366720!7318052!32366720
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suck abstract from ncbi


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pmid32366720      Antimicrob+Agents+Chemother 2020 ; 64 (7): ä
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  • Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs #MMPMID32366720
  • Jeon S; Ko M; Lee J; Choi I; Byun SY; Park S; Shum D; Kim S
  • Antimicrob Agents Chemother 2020[Jun]; 64 (7): ä PMID32366720show ga
  • Drug repositioning is the only feasible option to immediately address the COVID-19 global challenge. We screened a panel of 48 FDA-approved drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which were preselected by an assay of SARS-CoV. We identified 24 potential antiviral drug candidates against SARS-CoV-2 infection. Some drug candidates showed very low 50% inhibitory concentrations (IC(50)s), and in particular, two FDA-approved drugs-niclosamide and ciclesonide-were notable in some respects.
  • |*Drug Repositioning[MESH]
  • |Animals[MESH]
  • |Anti-Inflammatory Agents/pharmacology[MESH]
  • |Antiviral Agents/pharmacology[MESH]
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |Cell Line[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Drug Evaluation, Preclinical/methods[MESH]
  • |Humans[MESH]
  • |Niclosamide/*pharmacology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Pregnenediones/*pharmacology[MESH]
  • |SARS-CoV-2[MESH]


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