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10.1080/14787210.2020.1761333

http://scihub22266oqcxt.onion/10.1080/14787210.2020.1761333
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32366131!7212535!32366131
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suck abstract from ncbi


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pmid32366131      Expert+Rev+Anti+Infect+Ther 2020 ; 18 (8): 799-805
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  • Harnessing the potential of CRISPR-based platforms to advance the field of hospital medicine #MMPMID32366131
  • McCarthy MW
  • Expert Rev Anti Infect Ther 2020[Aug]; 18 (8): 799-805 PMID32366131show ga
  • INTRODUCTION: Clustered regularly interspaced short palindromic repeats (CRISPR) are segments of nucleic acid that play a role in prokaryotic defense and form the basis of a genome editing technology that allows permanent alteration of genetic material. This methodology, known as CRISPR-Cas9, is poised to revolutionize molecular biology, but no literature yet exists on how these advances will affect hospitalists. AREAS COVERED: These specialists in inpatient medicine care for a wide variety of hospitalized patients, including those with infectious disease, cancer, cardiovascular disease, autoimmune disease, hematologic disease, and a variety of other conditions that may soon be impacted by advances in gene-modifying technology provided by CRISPR-Cas9. A Literature search was performed using PubMed [1 December 2019-17 April 2020]. EXPERT OPINION: This paper reviews the remarkable diagnostic and therapeutic potential of the CRISPR-Cas9 platform and concludes with a look at ethical issues and technical hurdles pertaining to the implementation of permanent gene modification in the practice of Hospital Medicine.
  • |*CRISPR-Cas Systems[MESH]
  • |*Hospital Medicine[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/therapy[MESH]
  • |Gene Editing/methods[MESH]
  • |Genetic Therapy/*methods[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/therapy[MESH]


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