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10.3390/v12050497 http://scihub22266oqcxt.onion/10.3390/v12050497 32365751!7291053!32365751     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (5): ä Nephropedia Template TP {{tp|p=32365751|t=2020. The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor |pdf=|usr=}}{{32365751}} gab.com Text The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32365751 #FOAvip The COVID-19 disease has plagued over 200 countries with over three million cases and has resulted in over 200,000 deaths within 3 months. To gain insight into the high infection rate of the SARS-CoV-2 virus, we compare the interaction between the human ACE2 receptor and the SARS-CoV-2 spike protein with that of other pathogenic coronaviruses using molecular dynamics simulations. SARS-CoV, SARS-CoV-2, and HCoV-NL63 recognize ACE2 as the natural receptor but present a distinct binding interface to ACE2 and a different network of residue-residue contacts. SARS-CoV and SARS-CoV-2 have comparable binding affinities achieved by balancing energetics and dynamics. The SARS-CoV-2-ACE2 complex contains a higher number of contacts, a larger interface area, and decreased interface residue fluctuations relative to the SARS-CoV-ACE2 complex. These findings expose an exceptional evolutionary exploration exerted by coronaviruses toward host recognition. We postulate that the versatility of cell receptor binding strategies has immediate implications for therapeutic strategies. Twit Text FOAVip The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32365751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32365751 #FOAvip English Wikipedia <ref>{{Cite pmid|32365751}}</ref> The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human Receptor #MMPMID32365751 Brielle ES; Schneidman-Duhovny D; Linial M Viruses 2020[Apr]; 12 (5): ä PMID32365751show ga The COVID-19 disease has plagued over 200 countries with over three million cases and has resulted in over 200,000 deaths within 3 months. To gain insight into the high infection rate of the SARS-CoV-2 virus, we compare the interaction between the human ACE2 receptor and the SARS-CoV-2 spike protein with that of other pathogenic coronaviruses using molecular dynamics simulations. SARS-CoV, SARS-CoV-2, and HCoV-NL63 recognize ACE2 as the natural receptor but present a distinct binding interface to ACE2 and a different network of residue-residue contacts. SARS-CoV and SARS-CoV-2 have comparable binding affinities achieved by balancing energetics and dynamics. The SARS-CoV-2-ACE2 complex contains a higher number of contacts, a larger interface area, and decreased interface residue fluctuations relative to the SARS-CoV-ACE2 complex. These findings expose an exceptional evolutionary exploration exerted by coronaviruses toward host recognition. We postulate that the versatility of cell receptor binding strategies has immediate implications for therapeutic strategies. |*Receptors, Virus[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/chemistry/*metabolism[MESH] |Coronavirus NL63, Human/chemistry/metabolism[MESH] |Humans[MESH] |Molecular Dynamics Simulation[MESH] |Peptidyl-Dipeptidase A/*chemistry/metabolism[MESH] |Protein Domains[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/chemistry/metabolism[MESH]The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the (epmc).pdf DeepDyve Pubget Overpricing