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10.3390/molecules25092076

http://scihub22266oqcxt.onion/10.3390/molecules25092076
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32365556!7248959!32365556
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suck abstract from ncbi


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pmid32365556      Molecules 2020 ; 25 (9): ä
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  • Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-gamma as Candidates for Cytokine Storm Modulation in COVID-19 Disease #MMPMID32365556
  • Ciavarella C; Motta I; Valente S; Pasquinelli G
  • Molecules 2020[Apr]; 25 (9): ä PMID32365556show ga
  • The cytokine storm is an abnormal production of inflammatory cytokines, due to the over-activation of the innate immune response. This mechanism has been recognized as a critical mediator of influenza-induced lung disease, and it could be pivotal for COVID-19 infections. Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. In this regard, the peroxisome proliferator-activated receptor (PPAR)-gamma, a member of the PPAR transcription factor family, could represent a potential target. Beside the well-known regulatory role on lipid and glucose metabolism, PPAR-gamma also represses the inflammatory process. Similarly, the PPAR-gamma agonist thiazolidinediones (TZDs), like pioglitazone, are anti-inflammatory drugs with ameliorating effects on severe viral pneumonia. In addition to the pharmacological agonists, also nutritional ligands of PPAR-gamma, like curcuma, lemongrass, and pomegranate, possess anti-inflammatory properties through PPAR-gamma activation. Here, we review the main synthetic and nutritional PPAR-gamma ligands, proposing a dual approach based on the strengthening of the immune system using pharmacological and dietary strategies as an attempt to prevent/treat cytokine storm in the case of coronavirus infection.
  • |Animals[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/drug therapy/immunology/*pathology[MESH]
  • |Cytokines/antagonists & inhibitors[MESH]
  • |Fish Oils/pharmacology[MESH]
  • |Humans[MESH]
  • |Ligands[MESH]
  • |PPAR gamma/*agonists[MESH]
  • |Pandemics[MESH]
  • |Plants, Medicinal/*chemistry[MESH]
  • |Pneumonia, Viral/drug therapy/immunology/*pathology[MESH]
  • |Seafood/analysis[MESH]
  • |Spices/analysis[MESH]


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