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10.1002/alr.22602

http://scihub22266oqcxt.onion/10.1002/alr.22602
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suck abstract from ncbi


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pmid32363809      Int+Forum+Allergy+Rhinol 2020 ; 10 (7): 832-838
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  • Smell and taste symptom-based predictive model for COVID-19 diagnosis #MMPMID32363809
  • Roland LT; Gurrola JG 2nd; Loftus PA; Cheung SW; Chang JL
  • Int Forum Allergy Rhinol 2020[Jul]; 10 (7): 832-838 PMID32363809show ga
  • BACKGROUND: The presentation of coronavirus 2019 (COVID-19) overlaps with common influenza symptoms. There is limited data on whether a specific symptom or collection of symptoms may be useful to predict test positivity. METHODS: An anonymous electronic survey was publicized through social media to query participants with COVID-19 testing. Respondents were questioned regarding 10 presenting symptoms, demographic information, comorbidities, and COVID-19 test results. Stepwise logistic regression was used to identify predictors for COVID-19 positivity. Selected classifiers were assessed for prediction performance using receiver operating characteristic (ROC) curve analysis. RESULTS: A total of 145 participants with positive COVID-19 testing and 157 with negative results were included. Participants had a mean age of 39 years, and 214 (72%) were female. Smell or taste change, fever, and body ache were associated with COVID-19 positivity, and shortness of breath and sore throat were associated with a negative test result (p < 0.05). A model using all 5 diagnostic symptoms had the highest accuracy with a predictive ability of 82% in discriminating between COVID-19 results. To maximize sensitivity and maintain fair diagnostic accuracy, a combination of 2 symptoms, change in sense of smell or taste and fever was found to have a sensitivity of 70% and overall discrimination accuracy of 75%. CONCLUSION: Smell or taste change is a strong predictor for a COVID-19-positive test result. Using the presence of smell or taste change with fever, this parsimonious classifier correctly predicts 75% of COVID-19 test results. A larger cohort of respondents will be necessary to refine classifier performance.
  • |*Models, Theoretical[MESH]
  • |Adult[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*diagnosis/pathology/physiopathology[MESH]
  • |Female[MESH]
  • |Fever/physiopathology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/pathology/physiopathology[MESH]
  • |ROC Curve[MESH]
  • |SARS-CoV-2[MESH]
  • |Smell/*physiology[MESH]


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