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10.1016/j.healun.2020.03.008

http://scihub22266oqcxt.onion/10.1016/j.healun.2020.03.008
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suck abstract from ncbi


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pmid32362392      J+Heart+Lung+Transplant 2020 ; 39 (5): 412-417
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  • Epidemiologic and clinical characteristics of heart transplant recipients during the 2019 coronavirus outbreak in Wuhan, China: A descriptive survey report #MMPMID32362392
  • Ren ZL; Hu R; Wang ZW; Zhang M; Ruan YL; Wu ZY; Wu HB; Hu XP; Hu ZP; Ren W; Li LC; Dai FF; Liu H; Cai X
  • J Heart Lung Transplant 2020[May]; 39 (5): 412-417 PMID32362392show ga
  • BACKGROUND: The epidemiologic and clinical characteristics of heart transplant (HTx) recipients during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic remains unclear. We studied the characteristics of HTx recipients from December 20, 2019, to February 25, 2020, in an effort to understand their risk and outcomes. METHODS: All accessible HTx recipients were included in this single-center retrospective study. We collected information on the recipients using a web-based questionnaire as well as the hospital database. RESULTS: We followed 87 HTx recipients (72.4% were men, and the average age was 51 years). A total of 79 recipients resided in Hubei, and 57 recipients had a Wuhan-related history of travel or contact. Most took precautionary measures while in contact with suspicious crowds, and 96.6% of the families and communities undertook prevention and quarantine procedures. Four upper airway infections were reported, and 3 of them tested negative for SARS-CoV-2 (the fourth recovered and was not tested). All cases were mild and successfully recovered after proper treatment. Laboratory results of 47 HTx cases within the last 2 months were extracted. Of these, 21.3% of recipients had pre-existing lymphopenia, and 87.2% of recipients had a therapeutic concentration of tacrolimus (5-12 ng/ml). Liver and kidney insufficiency was seen in 5 and 6 recipients, respectively. CONCLUSION: HTx recipients who practiced appropriate prevention measures had a low rate of infection with SARS-CoV-2 and transition to the associated disease COVID-19. These early data will require confirmation as the pandemic establishes around the world.
  • |*Coronavirus/genetics/isolation & purification[MESH]
  • |*Heart Transplantation[MESH]
  • |Adult[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Coronavirus Infections/diagnosis/drug therapy/*epidemiology/prevention & control[MESH]
  • |Disease Outbreaks/*prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunosuppression Therapy[MESH]
  • |Immunosuppressive Agents/therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Peptidyl-Dipeptidase A/therapeutic use[MESH]
  • |Pneumonia, Viral/diagnosis/drug therapy/*epidemiology/prevention & control[MESH]
  • |Quarantine[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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