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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Iran+J+Kidney+Dis 2020 ; 14 (3): 167-172 Nephropedia Template TP
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How the COVID-19 Overcomes the Battle? An Approach to Virus Structure #MMPMID32361692
Ahmadpour D; Ahmadpoor P
Iran J Kidney Dis 2020[May]; 14 (3): 167-172 PMID32361692show ga
Coronaviruses primarily cause zoonotic infections, however in the past few decades several interspecies transmissions have occurred, the last one by SARS-CoV-2, causing COVID-19 pandemic, posing serious threat to global health. The SARS-CoV-2 spike (S) protein plays an important role in viral attachment, fusion and entry. However, other structural and non-structural SARS-CoV-2 proteins are potential influencers in virus pathogenicity. Among these proteins; Orf3, Orf8, and Orf10 show the least homology to SARSCoV proteins and therefore should be further studied for their abilities to modulate antiviral and inflammatory responses. Here, we discuss how SARS-COV-2 interacts with our immune system.