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suck abstract from ncbi


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pmid32361692      Iran+J+Kidney+Dis 2020 ; 14 (3): 167-172
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  • How the COVID-19 Overcomes the Battle? An Approach to Virus Structure #MMPMID32361692
  • Ahmadpour D; Ahmadpoor P
  • Iran J Kidney Dis 2020[May]; 14 (3): 167-172 PMID32361692show ga
  • Coronaviruses primarily cause zoonotic infections, however in the past few decades several interspecies transmissions have occurred, the last one by SARS-CoV-2, causing COVID-19 pandemic, posing serious threat to global health. The SARS-CoV-2 spike (S) protein plays an important role in viral attachment, fusion and entry. However, other structural and non-structural SARS-CoV-2 proteins are potential influencers in virus pathogenicity. Among these proteins; Orf3, Orf8, and Orf10 show the least homology to SARSCoV proteins and therefore should be further studied for their abilities to modulate antiviral and inflammatory responses. Here, we discuss how SARS-COV-2 interacts with our immune system.
  • |*Betacoronavirus/genetics/immunology[MESH]
  • |Animals[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*immunology/*virology[MESH]
  • |Gene Order[MESH]
  • |Genome, Viral/*genetics[MESH]
  • |Humans[MESH]
  • |Immune System/*virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology/*virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/genetics/immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/genetics/metabolism[MESH]
  • |Viral Proteins/*genetics/*metabolism[MESH]
  • |Viral Structures/genetics[MESH]


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