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10.1016/j.phrs.2020.104874

http://scihub22266oqcxt.onion/10.1016/j.phrs.2020.104874
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32360581!7192107!32360581
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suck abstract from ncbi


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pmid32360581      Pharmacol+Res 2020 ; 157 (ä): 104874
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  • Nitazoxanide/azithromycin combination for COVID-19: A suggested new protocol for early management #MMPMID32360581
  • Kelleni MT
  • Pharmacol Res 2020[Jul]; 157 (ä): 104874 PMID32360581show ga
  • Azithromycin has been shown to have a clinical efficacy against severe acute respiratory syndrome coronavirus 2; ivermectin has also demonstrated a remarkable experimental efficacy with a potential to be used for Coronavirus disease 2019. Further, BCG vaccination is being considered for clinical trials aiming to test its potential for lowering COVID-19 morbidity and mortality. This article illustrates some structural and functional relationships that may gather these drugs and the author, basing on a combined pathophysiological and pharmacological approach, recommends the FDA-approved antidiarrhea drug; nitazoxanide, which has been previously suggested but unfortunately widely ignored, to be tested in combination with azithromycin for their potential activity against SARS CoV-2, soonest. The author also recommends testing their combined administration as early during the clinical course of COVID-19 as possible. Further, basing on the same represented concept, the author suggests more trials for interferons to be tested against SARS CoV-2, especially in severe and critical COVID-19 cases.
  • |Antiparasitic Agents/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Azithromycin/*therapeutic use[MESH]
  • |Betacoronavirus/drug effects[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Drug Therapy, Combination/*methods[MESH]
  • |Humans[MESH]
  • |Nitro Compounds[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |SARS-CoV-2[MESH]


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