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  • Natural product-derived phytochemicals as potential agents against coronaviruses: A review #MMPMID32360300
  • Mani JS; Johnson JB; Steel JC; Broszczak DA; Neilsen PM; Walsh KB; Naiker M
  • Virus Res 2020[Jul]; 284 (ä): 197989 PMID32360300show ga
  • Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents for many coronavirus strains. Naturally existing compounds provide a wealth of chemical diversity, including antiviral activity, and thus may have utility as therapeutic agents against coronaviral infections. The PubMed database was searched for papers including the keywords coronavirus, SARS or MERS, as well as traditional medicine, herbal, remedy or plants, with 55 primary research articles identified. The overwhelming majority of publications focussed on polar compounds. Compounds that show promise for the inhibition of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, saikosaponin B2, quercetin, myricetin, caffeic acid, psoralidin, isobavachalcone, and lectins such as griffithsin. Other compounds such as lycorine may be suitable if a therapeutic level of antiviral activity can be achieved without exceeding toxic plasma concentrations. It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.
  • |Animals[MESH]
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Coronavirus, Feline/drug effects[MESH]
  • |Humans[MESH]
  • |Infectious bronchitis virus/drug effects[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/drug effects[MESH]
  • |Pandemics[MESH]
  • |Phytochemicals/*therapeutic use[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Porcine epidemic diarrhea virus/drug effects[MESH]
  • |SARS Virus/drug effects[MESH]
  • |SARS-CoV-2[MESH]

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  • suck abstract from ncbi

    197989 ä.284 2020