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10.1016/j.bmcl.2020.127218 http://scihub22266oqcxt.onion/10.1016/j.bmcl.2020.127218 32360102!7194799!32360102     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32360102&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Bioorg+Med+Chem+Lett 2020 ; 30 (13): 127218 Nephropedia Template TP {{tp|p=32360102|t=2020. The relationship between the structure and toxicity of aminoglycoside antibiotics |pdf=|usr=}}{{32360102}} gab.com Text The relationship between the structure and toxicity of aminoglycoside antibiotics JO: Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=32360102 #FOAvip Aminoglycoside antibiotics, used to treat persistent gram-negative infections, tuberculosis, and life-threatening infections in neonates and patients with cystic fibrosis, can infer acute kidney injury and irreversible hearing loss. The full repertoire of cellular targets and processes leading to the toxicity of aminoglycosides is not fully resolved, making it challenging to devise rational directions to circumvent their adverse effects. As a result, there has been very limited effort to rationally address the issue of aminoglycoside-induced toxicity. Here we provide an overview of the reported effects of aminoglycosides on cells of the inner ear and on kidney tubular epithelial cells. We describe selected examples for structure-toxicity relationships established by evaluation of both natural and semisynthetic aminoglycosides. The various assays and models used to evaluate these antibiotics and recent progress in development of safer aminoglycoside antibiotics are discussed. Twit Text FOAVip The relationship between the structure and toxicity of aminoglycoside antibiotics ????Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=32360102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32360102 #FOAvip English Wikipedia <ref>{{Cite pmid|32360102}}</ref> The relationship between the structure and toxicity of aminoglycoside antibiotics #MMPMID32360102 Jospe-Kaufman M; Siomin L; Fridman M Bioorg Med Chem Lett 2020[Jul]; 30 (13): 127218 PMID32360102show ga Aminoglycoside antibiotics, used to treat persistent gram-negative infections, tuberculosis, and life-threatening infections in neonates and patients with cystic fibrosis, can infer acute kidney injury and irreversible hearing loss. The full repertoire of cellular targets and processes leading to the toxicity of aminoglycosides is not fully resolved, making it challenging to devise rational directions to circumvent their adverse effects. As a result, there has been very limited effort to rationally address the issue of aminoglycoside-induced toxicity. Here we provide an overview of the reported effects of aminoglycosides on cells of the inner ear and on kidney tubular epithelial cells. We describe selected examples for structure-toxicity relationships established by evaluation of both natural and semisynthetic aminoglycosides. The various assays and models used to evaluate these antibiotics and recent progress in development of safer aminoglycoside antibiotics are discussed. |Aminoglycosides/chemistry/pharmacology/*toxicity[MESH] |Animals[MESH] |Anti-Bacterial Agents/chemistry/pharmacology/*toxicity[MESH] |Bacteria/drug effects[MESH] |Ear, Inner/drug effects[MESH] |Epithelial Cells/drug effects[MESH] |Humans[MESH] |Kidney Tubules/cytology[MESH]The relationship between the structure and toxicity of aminoglycoside (epmc).pdf DeepDyve Pubget Overpricing