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10.1016/j.mayocp.2020.03.024

http://scihub22266oqcxt.onion/10.1016/j.mayocp.2020.03.024
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32359771!7141471!32359771
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suck abstract from ncbi


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pmid32359771      Mayo+Clin+Proc 2020 ; 95 (6): 1213-1221
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  • Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19) #MMPMID32359771
  • Giudicessi JR; Noseworthy PA; Friedman PA; Ackerman MJ
  • Mayo Clin Proc 2020[Jun]; 95 (6): 1213-1221 PMID32359771show ga
  • As the coronavirus disease 19 (COVID-19) global pandemic rages across the globe, the race to prevent and treat this deadly disease has led to the "off-label" repurposing of drugs such as hydroxychloroquine and lopinavir/ritonavir, which have the potential for unwanted QT-interval prolongation and a risk of drug-induced sudden cardiac death. With the possibility that a considerable proportion of the world's population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment.
  • |*Death, Sudden, Cardiac/etiology/prevention & control[MESH]
  • |*Hydroxychloroquine/administration & dosage/adverse effects[MESH]
  • |*Long QT Syndrome/chemically induced/mortality/therapy[MESH]
  • |*Lopinavir/administration & dosage/adverse effects[MESH]
  • |*Ritonavir/administration & dosage/adverse effects[MESH]
  • |*Torsades de Pointes/chemically induced/mortality/therapy[MESH]
  • |Anti-Infective Agents/administration & dosage/adverse effects[MESH]
  • |Betacoronavirus/drug effects/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/drug therapy/epidemiology[MESH]
  • |Drug Combinations[MESH]
  • |Drug Monitoring/methods[MESH]
  • |Drug Repositioning/ethics/methods[MESH]
  • |Electrocardiography/methods[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/epidemiology[MESH]
  • |Risk Adjustment/*methods[MESH]


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