Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1096/fj.202000967 http://scihub22266oqcxt.onion/10.1096/fj.202000967 32359101!7267506!32359101     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32359101&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FASEB+J 2020 ; 34 (6): 7265-7269 Nephropedia Template TP {{tp|p=32359101|t=2020. A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications |pdf=|usr=}}{{32359101}} gab.com Text A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=32359101 #FOAvip As of April 20, 2020, over time, the COVID-19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative that safe and effective pharmacotherapeutic strategies are rapidly explored to improve survival. In this paper, we use established and emerging evidence to propose a testable hypothesis that, a vicious positive feedback loop of des-Arg(9)-bradykinin- and bradykinin-mediated inflammation --> injury --> inflammation, likely precipitates life threatening respiratory complications in COVID-19. Through our hypothesis, we make the prediction that the FDA-approved molecule, icatibant, might be able to interrupt this feedback loop and, thereby, improve the clinical outcomes. This hypothesis could lead to basic, translational, and clinical studies aimed at reducing COVID-19 morbidity and mortality. Twit Text FOAVip A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=32359101 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32359101 #FOAvip English Wikipedia <ref>{{Cite pmid|32359101}}</ref> A hypothesized role for dysregulated bradykinin signaling in COVID-19 respiratory complications #MMPMID32359101 Roche JA; Roche R FASEB J 2020[Jun]; 34 (6): 7265-7269 PMID32359101show ga As of April 20, 2020, over time, the COVID-19 pandemic has resulted in 157 970 deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of ~6.8%. With the pandemic rapidly spreading, and health delivery systems being overwhelmed, it is imperative that safe and effective pharmacotherapeutic strategies are rapidly explored to improve survival. In this paper, we use established and emerging evidence to propose a testable hypothesis that, a vicious positive feedback loop of des-Arg(9)-bradykinin- and bradykinin-mediated inflammation --> injury --> inflammation, likely precipitates life threatening respiratory complications in COVID-19. Through our hypothesis, we make the prediction that the FDA-approved molecule, icatibant, might be able to interrupt this feedback loop and, thereby, improve the clinical outcomes. This hypothesis could lead to basic, translational, and clinical studies aimed at reducing COVID-19 morbidity and mortality. |*Betacoronavirus[MESH] |*Models, Biological[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Bradykinin B2 Receptor Antagonists/pharmacology/*therapeutic use[MESH] |Bradykinin/*analogs & derivatives/pharmacology/physiology/therapeutic use[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Compassionate Use Trials[MESH] |Coronavirus Infections/complications/drug therapy/*physiopathology[MESH] |Dyspnea/etiology/physiopathology[MESH] |Feedback, Physiological/drug effects[MESH] |Humans[MESH] |Inflammation[MESH] |Off-Label Use[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*physiology[MESH] |Pneumonia, Viral/complications/drug therapy/*physiopathology[MESH] |Receptors, Bradykinin/drug effects/physiology[MESH] |Receptors, Virus/*physiology[MESH]A hypothesized role for dysregulated bradykinin signaling in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing