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32358954!7197596!32358954
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suck abstract from ncbi


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pmid32358954      Clin+Infect+Dis 2020 ; 71 (9): 2459-2468
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  • Bacterial and Fungal Coinfection in Individuals With Coronavirus: A Rapid Review To Support COVID-19 Antimicrobial Prescribing #MMPMID32358954
  • Rawson TM; Moore LSP; Zhu N; Ranganathan N; Skolimowska K; Gilchrist M; Satta G; Cooke G; Holmes A
  • Clin Infect Dis 2020[Dec]; 71 (9): 2459-2468 PMID32358954show ga
  • BACKGROUND: To explore and describe the current literature surrounding bacterial/fungal coinfection in patients with coronavirus infection. METHODS: MEDLINE, EMBASE, and Web of Science were searched using broad-based search criteria relating to coronavirus and bacterial coinfection. Articles presenting clinical data for patients with coronavirus infection (defined as SARS-1, MERS, SARS-CoV-2, and other coronavirus) and bacterial/fungal coinfection reported in English, Mandarin, or Italian were included. Data describing bacterial/fungal coinfections, treatments, and outcomes were extracted. Secondary analysis of studies reporting antimicrobial prescribing in SARS-CoV-2 even in absence of coinfection was performed. RESULTS: 1007 abstracts were identified. Eighteen full texts reporting bacterial/fungal coinfection were included. Most studies did not identify or report bacterial/fungal coinfection (85/140; 61%). Nine of 18 (50%) studies reported on COVID-19, 5/18 (28%) on SARS-1, 1/18 (6%) on MERS, and 3/18 (17%) on other coronaviruses. For COVID-19, 62/806 (8%) patients were reported as experiencing bacterial/fungal coinfection during hospital admission. Secondary analysis demonstrated wide use of broad-spectrum antibacterials, despite a paucity of evidence for bacterial coinfection. On secondary analysis, 1450/2010 (72%) of patients reported received antimicrobial therapy. No antimicrobial stewardship interventions were described. For non-COVID-19 cases, bacterial/fungal coinfection was reported in 89/815 (11%) of patients. Broad-spectrum antibiotic use was reported. CONCLUSIONS: Despite frequent prescription of broad-spectrum empirical antimicrobials in patients with coronavirus-associated respiratory infections, there is a paucity of data to support the association with respiratory bacterial/fungal coinfection. Generation of prospective evidence to support development of antimicrobial policy and appropriate stewardship interventions specific for the COVID-19 pandemic is urgently required.
  • |*COVID-19 Drug Treatment[MESH]
  • |Anti-Infective Agents/*therapeutic use[MESH]
  • |Antimicrobial Stewardship[MESH]
  • |Bacterial Infections/drug therapy/epidemiology/microbiology[MESH]
  • |COVID-19/epidemiology/microbiology[MESH]
  • |Coinfection/*drug therapy/epidemiology/microbiology[MESH]
  • |Drug Resistance, Microbial[MESH]
  • |Humans[MESH]
  • |Mycoses/drug therapy/epidemiology/microbiology[MESH]


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