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10.1261/rna.076232.120 http://scihub22266oqcxt.onion/10.1261/rna.076232.120 32358057!7297120!32358057     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       RNA 2020 ; 26 (7): 771-783 Nephropedia Template TP {{tp|p=32358057|t=2020. Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection |pdf=|usr=}}{{32358057}} gab.com Text Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection JO: RNA http://www.kidney.de/pget.php?&tw=1&pmid=32358057 #FOAvip The current COVID-19 pandemic presents a serious public health crisis, and a better understanding of the scope and spread of the virus would be aided by more widespread testing. Nucleic-acid-based tests currently offer the most sensitive and early detection of COVID-19. However, the "gold standard" test pioneered by the U.S. Centers for Disease Control and Prevention takes several hours to complete and requires extensive human labor, materials such as RNA extraction kits that could become in short supply, and relatively scarce qPCR machines. It is clear that a huge effort needs to be made to scale up current COVID-19 testing by orders of magnitude. There is thus a pressing need to evaluate alternative protocols, reagents, and approaches to allow nucleic-acid testing to continue in the face of these potential shortages. There has been a tremendous explosion in the number of papers written within the first weeks of the pandemic evaluating potential advances, comparable reagents, and alternatives to the "gold-standard" CDC RT-PCR test. Here we present a collection of these recent advances in COVID-19 nucleic acid testing, including both peer-reviewed and preprint articles. Due to the rapid developments during this crisis, we have included as many publications as possible, but many of the cited sources have not yet been peer-reviewed, so we urge researchers to further validate results in their own laboratories. We hope that this review can urgently consolidate and disseminate information to aid researchers in designing and implementing optimized COVID-19 testing protocols to increase the availability, accuracy, and speed of widespread COVID-19 testing. Twit Text FOAVip Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection ????RNA http://www.kidney.de/pget.php?&tw=1&pmid=32358057 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32358057 #FOAvip English Wikipedia <ref>{{Cite pmid|32358057}}</ref> Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection #MMPMID32358057 Esbin MN; Whitney ON; Chong S; Maurer A; Darzacq X; Tjian R RNA 2020[Jul]; 26 (7): 771-783 PMID32358057show ga The current COVID-19 pandemic presents a serious public health crisis, and a better understanding of the scope and spread of the virus would be aided by more widespread testing. Nucleic-acid-based tests currently offer the most sensitive and early detection of COVID-19. However, the "gold standard" test pioneered by the U.S. Centers for Disease Control and Prevention takes several hours to complete and requires extensive human labor, materials such as RNA extraction kits that could become in short supply, and relatively scarce qPCR machines. It is clear that a huge effort needs to be made to scale up current COVID-19 testing by orders of magnitude. There is thus a pressing need to evaluate alternative protocols, reagents, and approaches to allow nucleic-acid testing to continue in the face of these potential shortages. There has been a tremendous explosion in the number of papers written within the first weeks of the pandemic evaluating potential advances, comparable reagents, and alternatives to the "gold-standard" CDC RT-PCR test. Here we present a collection of these recent advances in COVID-19 nucleic acid testing, including both peer-reviewed and preprint articles. Due to the rapid developments during this crisis, we have included as many publications as possible, but many of the cited sources have not yet been peer-reviewed, so we urge researchers to further validate results in their own laboratories. We hope that this review can urgently consolidate and disseminate information to aid researchers in designing and implementing optimized COVID-19 testing protocols to increase the availability, accuracy, and speed of widespread COVID-19 testing. |*Clinical Laboratory Techniques[MESH] |Betacoronavirus/genetics/*isolation & purification[MESH] |COVID-19 Testing[MESH] |CRISPR-Cas Systems[MESH] |Centers for Disease Control and Prevention, U.S.[MESH] |Clustered Regularly Interspaced Short Palindromic Repeats[MESH] |Coronavirus Infections/diagnosis[MESH] |Humans[MESH] |Nasopharynx/virology[MESH] |Nucleic Acid Amplification Techniques/instrumentation/*methods[MESH] |Point-of-Care Systems[MESH] |RNA, Viral/genetics/isolation & purification[MESH] |Real-Time Polymerase Chain Reaction/instrumentation/*methods[MESH] |SARS-CoV-2[MESH] |Time Factors[MESH] |United States[MESH]Overcoming the bottleneck to widespread testing: a rapid review of nuc(epmc).pdf DeepDyve Pubget Overpricing