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Clin Pharmacol Ther 2020[Oct]; 108 (4): 699-702 PMID32356569show ga
The unprecedented challenges posed by the coronavirus disease 2019 (COVID-19) pandemic highlight the urgency for applying clinical pharmacology and model-informed drug development in (i) dosage optimization for COVID-19 therapies, (ii) approaching therapeutic dilemmas in clinical trial settings, and (iii) maximizing value of information from impacted non-COVID-19 trials. More than ever, we have a responsibility for adaptive evidence synthesis with a Totality of Evidence mindset in this race against time across biomedical research, clinical practice, drug development, and regulation.
|*Betacoronavirus[MESH]
|COVID-19[MESH]
|Clinical Trials as Topic/*methods/standards[MESH]