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10.1016/j.nmni.2020.100689

http://scihub22266oqcxt.onion/10.1016/j.nmni.2020.100689
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suck abstract from ncbi


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pmid32355564      New+Microbes+New+Infect 2020 ; 35 (ä): 100689
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  • Consideration of dornase alfa for the treatment of severe COVID-19 acute respiratory distress syndrome #MMPMID32355564
  • Earhart AP; Holliday ZM; Hofmann HV; Schrum AG
  • New Microbes New Infect 2020[May]; 35 (ä): 100689 PMID32355564show ga
  • We propose a likely contribution to severe COVID-19 morbidity by extracellular DNA in neutrophil extracellular traps (NETs). Dornase alfa degrades extracellular DNA to reduce mucus rigidity and accumulation, and was associated with respiratory improvement in a first patient. Dornase alfa should be considered for clinical trials in treatment of severe COVID-19.
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