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10.1016/j.thromres.2020.04.024

http://scihub22266oqcxt.onion/10.1016/j.thromres.2020.04.024
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suck abstract from ncbi


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pmid32353746      Thromb+Res 2020 ; 191 (ä): 9-14
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  • Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy #MMPMID32353746
  • Lodigiani C; Iapichino G; Carenzo L; Cecconi M; Ferrazzi P; Sebastian T; Kucher N; Studt JD; Sacco C; Bertuzzi A; Sandri MT; Barco S
  • Thromb Res 2020[Jul]; 191 (ä): 9-14 PMID32353746show ga
  • BACKGROUND: Few data are available on the rate and characteristics of thromboembolic complications in hospitalized patients with COVID-19. METHODS: We studied consecutive symptomatic patients with laboratory-proven COVID-19 admitted to a university hospital in Milan, Italy (13.02.2020-10.04.2020). The primary outcome was any thromboembolic complication, including venous thromboembolism (VTE), ischemic stroke, and acute coronary syndrome (ACS)/myocardial infarction (MI). Secondary outcome was overt disseminated intravascular coagulation (DIC). RESULTS: We included 388 patients (median age 66 years, 68% men, 16% requiring intensive care [ICU]). Thromboprophylaxis was used in 100% of ICU patients and 75% of those on the general ward. Thromboembolic events occurred in 28 (7.7% of closed cases; 95%CI 5.4%-11.0%), corresponding to a cumulative rate of 21% (27.6% ICU, 6.6% general ward). Half of the thromboembolic events were diagnosed within 24 h of hospital admission. Forty-four patients underwent VTE imaging tests and VTE was confirmed in 16 (36%). Computed tomography pulmonary angiography (CTPA) was performed in 30 patients, corresponding to 7.7% of total, and pulmonary embolism was confirmed in 10 (33% of CTPA). The rate of ischemic stroke and ACS/MI was 2.5% and 1.1%, respectively. Overt DIC was present in 8 (2.2%) patients. CONCLUSIONS: The high number of arterial and, in particular, venous thromboembolic events diagnosed within 24 h of admission and the high rate of positive VTE imaging tests among the few COVID-19 patients tested suggest that there is an urgent need to improve specific VTE diagnostic strategies and investigate the efficacy and safety of thromboprophylaxis in ambulatory COVID-19 patients.
  • |Acute Coronary Syndrome/epidemiology/etiology[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Ambulatory Care[MESH]
  • |Anticoagulants/therapeutic use[MESH]
  • |Arterial Occlusive Diseases/diagnostic imaging/epidemiology/*etiology[MESH]
  • |Brain Ischemia/epidemiology/etiology[MESH]
  • |COVID-19[MESH]
  • |Comorbidity[MESH]
  • |Coronary Thrombosis/diagnostic imaging/epidemiology/etiology[MESH]
  • |Coronavirus Infections/*complications[MESH]
  • |Critical Care[MESH]
  • |Disseminated Intravascular Coagulation/epidemiology/etiology[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Hospitals, Teaching/statistics & numerical data[MESH]
  • |Hospitals, Urban/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Length of Stay/statistics & numerical data[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Patient Admission[MESH]
  • |Pneumonia, Viral/*complications[MESH]
  • |Pulmonary Embolism/diagnostic imaging/epidemiology/etiology[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |Thrombophilia/drug therapy/*etiology[MESH]


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