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10.1016/j.ygeno.2020.04.016 http://scihub22266oqcxt.onion/10.1016/j.ygeno.2020.04.016 32353474!7184998!32353474     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genomics 2020 ; 112 (5): 3588-3596 Nephropedia Template TP {{tp|p=32353474|t=2020. Genotyping coronavirus SARS-CoV-2: methods and implications |pdf=|usr=}}{{32353474}} gab.com Text Genotyping coronavirus SARS-CoV-2: methods and implications JO: Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32353474 #FOAvip The emerging global infectious COVID-19 disease by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) presents critical threats to global public health and the economy since it was identified in late December 2019 in China. The virus has gone through various pathways of evolution. To understand the evolution and transmission of SARS-CoV-2, genotyping of virus isolates is of great importance. This study presents an accurate method for effectively genotyping SARS-CoV-2 viruses using complete genomes. The method employs the multiple sequence alignments of the genome isolates with the SARS-CoV-2 reference genome. The single-nucleotide polymorphism (SNP) genotypes are then measured by Jaccard distances to track the relationship of virus isolates. The genotyping analysis of SARS-CoV-2 isolates from the globe reveals that specific multiple mutations are the predominated mutation type during the current epidemic. The proposed method serves an effective tool for monitoring and tracking the epidemic of pathogenic viruses in their global and local genetic variations. The genotyping analysis shows that the genes encoding the S proteins and RNA polymerase, RNA primase, and nucleoprotein, undergo frequent mutations. These mutations are critical for vaccine development in disease control. Twit Text FOAVip Genotyping coronavirus SARS-CoV-2: methods and implications ????Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32353474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32353474 #FOAvip English Wikipedia <ref>{{Cite pmid|32353474}}</ref> Genotyping coronavirus SARS-CoV-2: methods and implications #MMPMID32353474 Yin C Genomics 2020[Sep]; 112 (5): 3588-3596 PMID32353474show ga The emerging global infectious COVID-19 disease by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) presents critical threats to global public health and the economy since it was identified in late December 2019 in China. The virus has gone through various pathways of evolution. To understand the evolution and transmission of SARS-CoV-2, genotyping of virus isolates is of great importance. This study presents an accurate method for effectively genotyping SARS-CoV-2 viruses using complete genomes. The method employs the multiple sequence alignments of the genome isolates with the SARS-CoV-2 reference genome. The single-nucleotide polymorphism (SNP) genotypes are then measured by Jaccard distances to track the relationship of virus isolates. The genotyping analysis of SARS-CoV-2 isolates from the globe reveals that specific multiple mutations are the predominated mutation type during the current epidemic. The proposed method serves an effective tool for monitoring and tracking the epidemic of pathogenic viruses in their global and local genetic variations. The genotyping analysis shows that the genes encoding the S proteins and RNA polymerase, RNA primase, and nucleoprotein, undergo frequent mutations. These mutations are critical for vaccine development in disease control. |*Genomics[MESH] |*Mutation[MESH] |*Polymorphism, Single Nucleotide[MESH] |Betacoronavirus/*genetics[MESH] |COVID-19[MESH] |Coronavirus Infections[MESH] |Evolution, Molecular[MESH] |Genome, Viral[MESH] |Genotyping Techniques/*methods[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral[MESH] |SARS-CoV-2[MESH]Genotyping coronavirus SARS-CoV-2: methods and implications (epmc).pdf DeepDyve Pubget Overpricing