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10.24272/j.issn.2095-8137.2020.022

http://scihub22266oqcxt.onion/10.24272/j.issn.2095-8137.2020.022
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32351056!7231477!32351056
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suck abstract from ncbi

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  • Decoding the evolution and transmissions of the novel pneumonia coronavirus (SARS-CoV-2 / HCoV-19) using whole genomic data #MMPMID32351056
  • Yu WB; Tang GD; Zhang L; Corlett RT
  • Zool Res 2020[May]; 41 (3): 247-257 PMID32351056show ga
  • The outbreak of COVID-19 started in mid-December 2019 in Wuhan, China. Up to 29 February 2020, SARS-CoV-2 (HCoV-19 / 2019-nCoV) had infected more than 85 000 people in the world. In this study, we used 93 complete genomes of SARS-CoV-2 from the GISAID EpiFlu (TM) database to investigate the evolution and human-to-human transmissions of SARS-CoV-2 in the first two months of the outbreak. We constructed haplotypes of the SARS-CoV-2 genomes, performed phylogenomic analyses and estimated the potential population size changes of the virus. The date of population expansion was calculated based on the expansion parameter tau ( tau) using the formula t= tau/2 u. A total of 120 substitution sites with 119 codons, including 79 non-synonymous and 40 synonymous substitutions, were found in eight coding-regions in the SARS-CoV-2 genomes. Forty non-synonymous substitutions are potentially associated with virus adaptation. No combinations were detected. The 58 haplotypes (31 found in samples from China and 31 from outside China) were identified in 93 viral genomes under study and could be classified into five groups. By applying the reported bat coronavirus genome (bat-RaTG13-CoV) as the outgroup, we found that haplotypes H13 and H38 might be considered as ancestral haplotypes, and later H1 was derived from the intermediate haplotype H3. The population size of the SARS-CoV-2 was estimated to have undergone a recent expansion on 06 January 2020, and an early expansion on 08 December 2019. Furthermore, phyloepidemiologic approaches have recovered specific directions of human-to-human transmissions and the potential sources for international infected cases.
  • |Animals[MESH]
  • |Base Sequence[MESH]
  • |Betacoronavirus/classification/*genetics[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/epidemiology/*transmission/*virology[MESH]
  • |Genetic Variation[MESH]
  • |Genome, Viral[MESH]
  • |Haplotypes[MESH]
  • |Humans[MESH]
  • |Likelihood Functions[MESH]
  • |Pandemics[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/epidemiology/*transmission/*virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Zoonoses[MESH]


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  • suck abstract from ncbi

    247 3.41 2020