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10.1111/ajt.15967

http://scihub22266oqcxt.onion/10.1111/ajt.15967
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32351040!7267603!32351040
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  • COVID-19 in kidney transplant recipients #MMPMID32351040
  • Nair V; Jandovitz N; Hirsch JS; Nair G; Abate M; Bhaskaran M; Grodstein E; Berlinrut I; Hirschwerk D; Cohen SL; Davidson KW; Dominello AJ; Osorio GA; Richardson S; Teperman LW; Molmenti EP
  • Am J Transplant 2020[Jul]; 20 (7): 1819-1825 PMID32351040show ga
  • There is minimal information on coronavirus disease 2019 (COVID-19) in immunocompromised individuals. We have studied 10 patients treated at 12 adult care hospitals. Ten kidney transplant recipients tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by polymerase chain reaction, and 9 were admitted. The median age was 57 (interquartile range [IQR] 47-67), 60% were male, 40% Caucasian, and 30% Black/African American. Median time from transplant to COVID-19 testing was 2822 days (IQR 1272-4592). The most common symptom was fever, followed by cough, myalgia, chills, and fatigue. The most common chest X-ray and computed tomography abnormality was multifocal patchy opacities. Three patients had no abnormal findings. Leukopenia was seen in 20% of patients, and allograft function was stable in 50% of patients. Nine patients were on tacrolimus and a mycophenolic antimetabolite, and 70% were on prednisone. Hospitalized patients had their antimetabolite agent stopped. All hospitalized patients received hydroxychloroquine and azithromycin. Three patients died (30%), and 5 (50%) developed acute kidney injury. Kidney transplant recipients infected with COVID-19 should be monitored closely in the setting of lowered immunosuppression. Most individuals required hospitalization and presenting symptoms were similar to those of nontransplant individuals.
  • |*Kidney Transplantation[MESH]
  • |*Transplant Recipients[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/*complications/diagnosis/mortality[MESH]
  • |Critical Care[MESH]
  • |Electronic Health Records[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunocompromised Host[MESH]
  • |Immunosuppression/adverse effects[MESH]
  • |Kidney Failure, Chronic/complications/*surgery/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |New York/epidemiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/mortality[MESH]
  • |SARS-CoV-2[MESH]


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  • suck abstract from ncbi

    1819 7.20 2020