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10.1007/s12471-020-01429-7

http://scihub22266oqcxt.onion/10.1007/s12471-020-01429-7
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32350818!7189353!32350818
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suck abstract from ncbi


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pmid32350818      Neth+Heart+J 2020 ; 28 (7-8): 406-409
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  • Chloroquine-induced QTc prolongation in COVID-19 patients #MMPMID32350818
  • van den Broek MPH; Mohlmann JE; Abeln BGS; Liebregts M; van Dijk VF; van de Garde EMW
  • Neth Heart J 2020[Jul]; 28 (7-8): 406-409 PMID32350818show ga
  • BACKGROUND: In the battle against the SARS-CoV?2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patients. A safety consideration for the application of chloroquine is its QTc-prolonging potential. Thus far, no data are available on the QTc-prolonging potential of chloroquine in COVID-19 patients. OBJECTIVE: To assess the degree of chloroquine-induced QTc prolongation in hospitalised COVID-19 patients. METHODS: A baseline electrocardiogram (ECG) and ECGs recorded during chloroquine treatment were retrospectively collected in patients suspected of having COVID-19. The QTc interval was calculated by computerised and manual interpretation. Baseline and follow-up QTc intervals were compared using the paired samples t-test. RESULTS: A total of 95 patients had a baseline ECG recording and at least one ECG recording during chloroquine therapy. Chloroquine treatment resulted in a mean QTc prolongation of 35?ms (95% CI 28-43?ms) using computerised interpretation and 34?ms (95% CI 25-43?ms) using manual interpretation. No torsade de pointes was observed during chloroquine treatment. After manual review, 22 patients (23%) had a QTc interval exceeding 500?ms during chloroquine treatment. None of these patients had a prolonged QTc interval prior to the initiation of chloroquine treatment. CONCLUSIONS: Chloroquine significantly prolongs the QTc interval in a clinically relevant matter. This highlights the need for ECG monitoring when prescribing chloroquine to COVID-19 patients.
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