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10.1007/s12471-020-01429-7 http://scihub22266oqcxt.onion/10.1007/s12471-020-01429-7 32350818!7189353!32350818     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32350818&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Neth+Heart+J 2020 ; 28 (7-8): 406-409 Nephropedia Template TP {{tp|p=32350818|t=2020. Chloroquine-induced QTc prolongation in COVID-19 patients |pdf=|usr=}}{{32350818}} gab.com Text Chloroquine-induced QTc prolongation in COVID-19 patients JO: Neth Heart J http://www.kidney.de/pget.php?&tw=1&pmid=32350818 #FOAvip BACKGROUND: In the battle against the SARS-CoV?2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patients. A safety consideration for the application of chloroquine is its QTc-prolonging potential. Thus far, no data are available on the QTc-prolonging potential of chloroquine in COVID-19 patients. OBJECTIVE: To assess the degree of chloroquine-induced QTc prolongation in hospitalised COVID-19 patients. METHODS: A baseline electrocardiogram (ECG) and ECGs recorded during chloroquine treatment were retrospectively collected in patients suspected of having COVID-19. The QTc interval was calculated by computerised and manual interpretation. Baseline and follow-up QTc intervals were compared using the paired samples t-test. RESULTS: A total of 95 patients had a baseline ECG recording and at least one ECG recording during chloroquine therapy. Chloroquine treatment resulted in a mean QTc prolongation of 35?ms (95% CI 28-43?ms) using computerised interpretation and 34?ms (95% CI 25-43?ms) using manual interpretation. No torsade de pointes was observed during chloroquine treatment. After manual review, 22 patients (23%) had a QTc interval exceeding 500?ms during chloroquine treatment. None of these patients had a prolonged QTc interval prior to the initiation of chloroquine treatment. CONCLUSIONS: Chloroquine significantly prolongs the QTc interval in a clinically relevant matter. This highlights the need for ECG monitoring when prescribing chloroquine to COVID-19 patients. Twit Text FOAVip Chloroquine-induced QTc prolongation in COVID-19 patients ????Neth Heart J http://www.kidney.de/pget.php?&tw=1&pmid=32350818 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32350818 #FOAvip English Wikipedia <ref>{{Cite pmid|32350818}}</ref> Chloroquine-induced QTc prolongation in COVID-19 patients #MMPMID32350818 van den Broek MPH; Mohlmann JE; Abeln BGS; Liebregts M; van Dijk VF; van de Garde EMW Neth Heart J 2020[Jul]; 28 (7-8): 406-409 PMID32350818show ga BACKGROUND: In the battle against the SARS-CoV?2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patients. A safety consideration for the application of chloroquine is its QTc-prolonging potential. Thus far, no data are available on the QTc-prolonging potential of chloroquine in COVID-19 patients. OBJECTIVE: To assess the degree of chloroquine-induced QTc prolongation in hospitalised COVID-19 patients. METHODS: A baseline electrocardiogram (ECG) and ECGs recorded during chloroquine treatment were retrospectively collected in patients suspected of having COVID-19. The QTc interval was calculated by computerised and manual interpretation. Baseline and follow-up QTc intervals were compared using the paired samples t-test. RESULTS: A total of 95 patients had a baseline ECG recording and at least one ECG recording during chloroquine therapy. Chloroquine treatment resulted in a mean QTc prolongation of 35?ms (95% CI 28-43?ms) using computerised interpretation and 34?ms (95% CI 25-43?ms) using manual interpretation. No torsade de pointes was observed during chloroquine treatment. After manual review, 22 patients (23%) had a QTc interval exceeding 500?ms during chloroquine treatment. None of these patients had a prolonged QTc interval prior to the initiation of chloroquine treatment. CONCLUSIONS: Chloroquine significantly prolongs the QTc interval in a clinically relevant matter. This highlights the need for ECG monitoring when prescribing chloroquine to COVID-19 patients. ?Chloroquine-induced QTc prolongation in COVID-19 patients (epmc).pdf DeepDyve Pubget Overpricing