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10.1097/APO.0000000000000289

http://scihub22266oqcxt.onion/10.1097/APO.0000000000000289
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32349115!7227199!32349115
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suck abstract from ncbi


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pmid32349115      Asia+Pac+J+Ophthalmol+(Phila) 2020 ; 9 (2): 85-87
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  • Chloroquine and Hydroxychloroquine Retinal Toxicity Consideration in the Treatment of COVID-19 #MMPMID32349115
  • Ruamviboonsuk P; Lai TYY; Chang A; Lai CC; Mieler WF; Lam DSC
  • Asia Pac J Ophthalmol (Phila) 2020[Mar]; 9 (2): 85-87 PMID32349115show ga
  • The proposed doses of chloroquine (CQ) and hydroxychloroquine (HCQ) for treatment of COVID-19 (1000 mg/day for 10 days, CQ; 800 mg first day then 400 mg/day for 5 days, HCQ) in many guidelines worldwide, are considerably higher than the maximum recommended daily safe doses of both agents (5 years. It is not known whether exposure to high doses over a short period of time can also cause the damage. We recommend that before prescribing CQ or HCQ, history of ocular disease should be obtained to avoid the prescription if appropriate. If either agent is to be used, routine baseline ocular examination is not absolutely necessary. Patients who do not have ocular disease should also be informed about the potential risk of retinal toxicity. Both agents, however, have not yet been proven to be beneficial to COVID-19.
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Chloroquine/administration & dosage/*toxicity[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/administration & dosage/*toxicity[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Retina/*drug effects/pathology[MESH]
  • |Retinal Diseases/chemically induced[MESH]
  • |Risk Factors[MESH]


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