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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Infect+Dis 2020 ; 222 (1): 34-37 Nephropedia Template TP
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Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019 #MMPMID32348495
Zhang Y; Qin L; Zhao Y; Zhang P; Xu B; Li K; Liang L; Zhang C; Dai Y; Feng Y; Sun J; Hu Z; Xiang H; Knight JC; Dong T; Jin R
J Infect Dis 2020[Jun]; 222 (1): 34-37 PMID32348495show ga
A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.