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10.1093/infdis/jiaa224

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa224
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suck abstract from ncbi


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pmid32348495      J+Infect+Dis 2020 ; 222 (1): 34-37
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  • Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019 #MMPMID32348495
  • Zhang Y; Qin L; Zhao Y; Zhang P; Xu B; Li K; Liang L; Zhang C; Dai Y; Feng Y; Sun J; Hu Z; Xiang H; Knight JC; Dong T; Jin R
  • J Infect Dis 2020[Jun]; 222 (1): 34-37 PMID32348495show ga
  • A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.
  • |*Alleles[MESH]
  • |*Polymorphism, Single Nucleotide[MESH]
  • |*Severity of Illness Index[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |COVID-19[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*genetics/virology[MESH]
  • |Female[MESH]
  • |Genotype[MESH]
  • |High-Throughput Nucleotide Sequencing[MESH]
  • |Homozygote[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Membrane Proteins/*genetics[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*genetics/virology[MESH]
  • |RNA-Binding Proteins/*genetics[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]


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