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10.1093/infdis/jiaa228

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa228
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32348485!7197534!32348485
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suck abstract from ncbi


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pmid32348485      J+Infect+Dis 2020 ; 222 (1): 38-43
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  • Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in Patients With Coronavirus Disease 2019 #MMPMID32348485
  • Zeng QL; Yu ZJ; Gou JJ; Li GM; Ma SH; Zhang GF; Xu JH; Lin WB; Cui GL; Zhang MM; Li C; Wang ZS; Zhang ZH; Liu ZS
  • J Infect Dis 2020[Jun]; 222 (1): 38-43 PMID32348485show ga
  • Currently, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported in almost all countries globally. No effective therapy has been documented for COVID-19, and the role of convalescent plasma therapy is unknown. In the current study, 6 patients with COVID-19 and respiratory failure received convalescent plasma a median of 21.5 days after viral shedding was first detected, all tested negative for SARS-CoV-2 RNA within 3 days after infusion, and 5 eventually died. In conclusion, convalescent plasma treatment can end SARS-CoV-2 shedding but cannot reduce the mortality rate in critically ill patients with end-stage COVID-19, and treatment should be initiated earlier.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*therapeutic use[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |Blood Donors[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*mortality/*therapy/virology[MESH]
  • |Critical Illness[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunization, Passive/adverse effects[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*mortality/*therapy/virology[MESH]
  • |RNA, Viral/genetics[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Survival Rate[MESH]
  • |Treatment Outcome[MESH]


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