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10.1042/BCJ20200223 http://scihub22266oqcxt.onion/10.1042/BCJ20200223 32348474!7200640!32348474     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+J 2020 ; 477 (8): 1479-1482 Nephropedia Template TP {{tp|p=32348474|t=2020. Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle |pdf=|usr=}}{{32348474}} gab.com Text Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle JO: Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=32348474 #FOAvip Coronavirus are the causative agents in many globally concerning respiratory disease outbreaks such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease-2019 (COVID-19). It is therefore important that we improve our understanding of how the molecular components of the virus facilitate the viral life cycle. These details will allow for the design of effective interventions. Krichel and coauthors in their article in the Biochemical Journal provide molecular details of how the viral polyprotein (nsp7-10) produced from the positive single stranded RNA genome, is cleaved to form proteins that are part of the replication/transcription complex. The authors highlight the impact the polyprotein conformation has on the cleavage efficiency of the main protease (Mpro) and hence the order of release of non-structural proteins 7-10 (nsp7-10) of the SARS-CoV. Cleavage order is important in controlling viral processes and seems to have relevance in terms of the protein-protein complexes formed. The authors made use of mass spectrometry to advance our understanding of the mechanism by which coronaviruses control nsp 7, 8, 9 and 10 production in the virus life cycle. Twit Text FOAVip Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle ????Biochem J http://www.kidney.de/pget.php?&tw=1&pmid=32348474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32348474 #FOAvip English Wikipedia <ref>{{Cite pmid|32348474}}</ref> Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle #MMPMID32348474 Gildenhuys S Biochem J 2020[Apr]; 477 (8): 1479-1482 PMID32348474show ga Coronavirus are the causative agents in many globally concerning respiratory disease outbreaks such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease-2019 (COVID-19). It is therefore important that we improve our understanding of how the molecular components of the virus facilitate the viral life cycle. These details will allow for the design of effective interventions. Krichel and coauthors in their article in the Biochemical Journal provide molecular details of how the viral polyprotein (nsp7-10) produced from the positive single stranded RNA genome, is cleaved to form proteins that are part of the replication/transcription complex. The authors highlight the impact the polyprotein conformation has on the cleavage efficiency of the main protease (Mpro) and hence the order of release of non-structural proteins 7-10 (nsp7-10) of the SARS-CoV. Cleavage order is important in controlling viral processes and seems to have relevance in terms of the protein-protein complexes formed. The authors made use of mass spectrometry to advance our understanding of the mechanism by which coronaviruses control nsp 7, 8, 9 and 10 production in the virus life cycle. |*Coronavirus[MESH] |*Coronavirus Infections[MESH] |*Severe acute respiratory syndrome-related coronavirus[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral[MESH] |Polyproteins[MESH] |SARS-CoV-2[MESH]Expanding our understanding of the role polyprotein conformation plays(epmc).pdf DeepDyve Pubget Overpricing