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10.1021/acschemneuro.0c00217

http://scihub22266oqcxt.onion/10.1021/acschemneuro.0c00217
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32348111!ä!32348111

suck abstract from ncbi


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pmid32348111      ACS+Chem+Neurosci 2020 ; 11 (10): 1379-1381
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  • Is the Collapse of the Respiratory Center in the Brain Responsible for Respiratory Breakdown in COVID-19 Patients? #MMPMID32348111
  • Gandhi S; Srivastava AK; Ray U; Tripathi PP
  • ACS Chem Neurosci 2020[May]; 11 (10): 1379-1381 PMID32348111show ga
  • Following the identification of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, we are now again facing a global highly pathogenic novel coronavirus (SARS-CoV-2) epidemic. Although the lungs are one of the most critically affected organs, several other organs, including the brain may also get infected. Here, we have highlighted that SARS-CoV-2 might infect the central nervous system (CNS) through the olfactory bulb. From the olfactory bulb, SARS-CoV-2 may target the deeper parts of the brain including the thalamus and brainstem by trans-synaptic transfer described for many other viral diseases. Following this, the virus might infect the respiratory center of brain, which could be accountable for the respiratory breakdown of COVID-19 patients. Therefore, it is important to screen the COVID-19 patients for neurological symptoms as well as possibility of the collapse of the respiratory center in the brainstem should be investigated in depth.
  • |Animals[MESH]
  • |Betacoronavirus/isolation & purification/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/epidemiology/*physiopathology/*virology[MESH]
  • |Disease Models, Animal[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Mice, Transgenic[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/epidemiology/*physiopathology/*virology[MESH]
  • |Respiration Disorders/physiopathology/*virology[MESH]
  • |Respiratory Center/physiopathology/*virology[MESH]
  • |SARS-CoV-2[MESH]


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  • suck abstract from ncbi

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