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10.1002/jmv.25957 http://scihub22266oqcxt.onion/10.1002/jmv.25957 32347972!7267262!32347972     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2020 ; 92 (10): 2036-2041 Nephropedia Template TP {{tp|p=32347972|t=2020. Elevations of serum cancer biomarkers correlate with severity of COVID-19 |pdf=|usr=}}{{32347972}} gab.com Text Elevations of serum cancer biomarkers correlate with severity of COVID-19 JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32347972 #FOAvip In this retrospective study, we evaluated the levels of a series of serum biomarkers in coronavirus disease 2019 (COVID-19) patients (mild: 131; severe: 98; critical: 23). We found that there were significant increases in levels of human epididymis protein 4 (HE4) (73.6 +/- 38.3 vs 46.5 +/- 14.7 pmol/L; P < .001), cytokeratin-19 fragment (CYFRA21-1) (2.2 +/- 0.9 vs 1.9 +/- 0.8 mug/L; P < .001), carcinoembryonic antigen (CEA) (3.4 +/- 2.2 vs 2.1 +/- 1.2 mug/L; P < .001), carbohydrate antigens (CA) 125 (18.1 +/- 13.5 vs 10.5 +/- 4.6 mug/L; P < .001), and 153 (14.4 +/- 8.9 vs 10.1 +/- 4.4 mug/L; P < .001) in COVID-19 mild cases as compared to normal control subjects; their levels showed continuous and significant increases in severe and critical cases (HE4, CYFRA21-1, and CA125: P < .001; CEA and CA153: P < .01). Squamous cell carcinoma antigen (SCC) and CA199 increased significantly only in critical cases of COVID-19 as compared with mild and severe cases and normal controls (P < .01). There were positive associations between levels of C-reactive protein and levels of HE4 (R = .631; P < .001), CYFRA21-1 (R = .431; P < .001), CEA (R = .316; P < .001), SCC (R = .351; P < .001), CA153 (R = .359; P < .001) and CA125 (R = .223; P = .031). We concluded that elevations of serum cancer biomarkers positively correlated with the pathological progressions of COVID-19, demonstrating diffuse and acute pathophysiological injuries in COVID-19. Twit Text FOAVip Elevations of serum cancer biomarkers correlate with severity of COVID-19 ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=32347972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32347972 #FOAvip English Wikipedia <ref>{{Cite pmid|32347972}}</ref> Elevations of serum cancer biomarkers correlate with severity of COVID-19 #MMPMID32347972 Wei X; Su J; Yang K; Wei J; Wan H; Cao X; Tan W; Wang H J Med Virol 2020[Oct]; 92 (10): 2036-2041 PMID32347972show ga In this retrospective study, we evaluated the levels of a series of serum biomarkers in coronavirus disease 2019 (COVID-19) patients (mild: 131; severe: 98; critical: 23). We found that there were significant increases in levels of human epididymis protein 4 (HE4) (73.6 +/- 38.3 vs 46.5 +/- 14.7 pmol/L; P < .001), cytokeratin-19 fragment (CYFRA21-1) (2.2 +/- 0.9 vs 1.9 +/- 0.8 mug/L; P < .001), carcinoembryonic antigen (CEA) (3.4 +/- 2.2 vs 2.1 +/- 1.2 mug/L; P < .001), carbohydrate antigens (CA) 125 (18.1 +/- 13.5 vs 10.5 +/- 4.6 mug/L; P < .001), and 153 (14.4 +/- 8.9 vs 10.1 +/- 4.4 mug/L; P < .001) in COVID-19 mild cases as compared to normal control subjects; their levels showed continuous and significant increases in severe and critical cases (HE4, CYFRA21-1, and CA125: P < .001; CEA and CA153: P < .01). Squamous cell carcinoma antigen (SCC) and CA199 increased significantly only in critical cases of COVID-19 as compared with mild and severe cases and normal controls (P < .01). There were positive associations between levels of C-reactive protein and levels of HE4 (R = .631; P < .001), CYFRA21-1 (R = .431; P < .001), CEA (R = .316; P < .001), SCC (R = .351; P < .001), CA153 (R = .359; P < .001) and CA125 (R = .223; P = .031). We concluded that elevations of serum cancer biomarkers positively correlated with the pathological progressions of COVID-19, demonstrating diffuse and acute pathophysiological injuries in COVID-19. |Aged[MESH] |Aged, 80 and over[MESH] |Antigens, Neoplasm/blood[MESH] |Antigens, Tumor-Associated, Carbohydrate/blood[MESH] |Biomarkers, Tumor/*blood[MESH] |C-Reactive Protein/analysis[MESH] |CA-125 Antigen/blood[MESH] |COVID-19/*blood/*diagnosis[MESH] |Case-Control Studies[MESH] |China[MESH] |Comorbidity[MESH] |Female[MESH] |Humans[MESH] |Keratin-19/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH] |Serpins/blood[MESH] |Severity of Illness Index[MESH]Elevations of serum cancer biomarkers correlate with severity of COVID(epmc).pdf DeepDyve Pubget Overpricing