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10.1152/physrev.00011.2019 http://scihub22266oqcxt.onion/10.1152/physrev.00011.2019 32347156!7474261!32347156     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rev 2020 ; 100 (3): 1119-1147 Nephropedia Template TP {{tp|p=32347156|t=2020. The Renal Physiology of Pendrin-Positive Intercalated Cells |pdf=|usr=}}{{32347156}} gab.com Text The Renal Physiology of Pendrin-Positive Intercalated Cells JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=32347156 #FOAvip Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl(-) absorption and HCO(3)(-) secretion, largely through the anion exchanger pendrin. This exchanger is thought to act in tandem with the Na(+)-dependent Cl(-)/HCO(3)(-) exchanger, NDCBE, to mediate net NaCl absorption. Pendrin is stimulated by angiotensin II and aldosterone administration via the angiotensin type 1a and the mineralocorticoid receptors, respectively. It is also stimulated in models of metabolic alkalosis, such as with NaHCO(3) administration. In some rodent models, pendrin-mediated HCO(3)(-) secretion modulates acid-base balance. However, of probably more physiological or clinical significance is the role of these pendrin-positive ICs in blood pressure regulation, which occurs, at least in part, through pendrin-mediated renal Cl(-) absorption, as well as their effect on the epithelial Na(+) channel, ENaC. Aldosterone stimulates ENaC directly through principal cell mineralocorticoid hormone receptor (ligand) binding and also indirectly through its effect on pendrin expression and function. In so doing, pendrin contributes to the aldosterone pressor response. Pendrin may also modulate blood pressure in part through its action in the adrenal medulla, where it modulates the release of catecholamines, or through an indirect effect on vascular contractile force. In addition to its role in Na(+) and Cl(-) balance, pendrin affects the balance of other ions, such as K(+) and I(-). This review describes how aldosterone and angiotensin II-induced signaling regulate pendrin and the contribution of pendrin-positive ICs in the kidney to distal nephron function and blood pressure. Twit Text FOAVip The Renal Physiology of Pendrin-Positive Intercalated Cells ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=32347156 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32347156 #FOAvip English Wikipedia <ref>{{Cite pmid|32347156}}</ref> The Renal Physiology of Pendrin-Positive Intercalated Cells #MMPMID32347156 Wall SM; Verlander JW; Romero CA Physiol Rev 2020[Jul]; 100 (3): 1119-1147 PMID32347156show ga Intercalated cells (ICs) are found in the connecting tubule and the collecting duct. Of the three IC subtypes identified, type B intercalated cells are one of the best characterized and known to mediate Cl(-) absorption and HCO(3)(-) secretion, largely through the anion exchanger pendrin. This exchanger is thought to act in tandem with the Na(+)-dependent Cl(-)/HCO(3)(-) exchanger, NDCBE, to mediate net NaCl absorption. Pendrin is stimulated by angiotensin II and aldosterone administration via the angiotensin type 1a and the mineralocorticoid receptors, respectively. It is also stimulated in models of metabolic alkalosis, such as with NaHCO(3) administration. In some rodent models, pendrin-mediated HCO(3)(-) secretion modulates acid-base balance. However, of probably more physiological or clinical significance is the role of these pendrin-positive ICs in blood pressure regulation, which occurs, at least in part, through pendrin-mediated renal Cl(-) absorption, as well as their effect on the epithelial Na(+) channel, ENaC. Aldosterone stimulates ENaC directly through principal cell mineralocorticoid hormone receptor (ligand) binding and also indirectly through its effect on pendrin expression and function. In so doing, pendrin contributes to the aldosterone pressor response. Pendrin may also modulate blood pressure in part through its action in the adrenal medulla, where it modulates the release of catecholamines, or through an indirect effect on vascular contractile force. In addition to its role in Na(+) and Cl(-) balance, pendrin affects the balance of other ions, such as K(+) and I(-). This review describes how aldosterone and angiotensin II-induced signaling regulate pendrin and the contribution of pendrin-positive ICs in the kidney to distal nephron function and blood pressure. |Acid-Base Equilibrium/drug effects/physiology[MESH] |Aldosterone/pharmacology[MESH] |Angiotensin II/pharmacology[MESH] |Animals[MESH] |Gene Expression Regulation/drug effects/physiology[MESH] |Humans[MESH] |Kidney/*cytology/*physiology[MESH]The Renal Physiology of Pendrin-Positive Intercalated Cells (epmc).pdf DeepDyve Pubget Overpricing