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  • Diagnosis, treatment, control and prevention of SARS-CoV-2 and coronavirus disease 2019: back to the future #MMPMID32347053
  • Ye ZW; Jin DY
  • Sheng Wu Gong Cheng Xue Bao 2020[Apr]; 36 (4): 571-592 PMID32347053show ga
  • The ongoing outbreak of the coronavirus disease 2019 (COVID-19) as named by the World Health Organization has millions of confirmed cases around the world and has claimed hundreds of thousands of lives. The virus was named SARS-CoV-2 in February by International Committee on Taxonomy of Viruses. COVID-19 presents as fever, dry cough, dyspnea, headache and pneumonia. In a small subset of severe cases, the disease quickly progresses to respiratory failure and even death. Since the 21st century, there have been three major outbreaks caused by human coronaviruses, including the severe acute respiratory syndrome (SARS) that broke out in 2003, the Middle East respiratory syndrome (MERS) in 2012, and the recent pandemic of COVID-19. Since 2003, significant progress has been made in the study of SARS-CoV and MERS-CoV concerning their natural origins, pathogenesis, antiviral development and vaccine design. Since SARS-CoV-2 and SARS-CoV are closely related, previous findings on SARS-CoV are highly relevant to a better understanding as well as diagnosis, treatment, prevention and control of SARS-CoV-2. In this review, we highlight recent progresses in the field; compare the biological characteristics of SARS-CoV and SARS-CoV-2; summarize the urgently-needed diagnostic, treatment, prevention and control options; and provide future perspectives for the outcome of the outbreak and research questions to be answered, including some of the difficulties in vaccine development. Hopefully, our comments and suggestions would prove useful for the control of the SARS-CoV-2 epidemic in China and the world.
  • |*Betacoronavirus/drug effects/immunology/pathogenicity[MESH]
  • |*Coronavirus Infections/diagnosis/prevention & control/therapy/virology[MESH]
  • |*Pandemics/prevention & control[MESH]
  • |*Pneumonia, Viral/diagnosis/prevention & control/therapy/virology[MESH]
  • |Antiviral Agents/pharmacology/therapeutic use[MESH]
  • |Humans[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/drug effects/immunology/pathogenicity[MESH]
  • |SARS Virus/drug effects/immunology/pathogenicity[MESH]
  • |Severe Acute Respiratory Syndrome/diagnosis/prevention & control/therapy/virology[MESH]
  • |Viral Vaccines[MESH]

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  • suck abstract from ncbi

    571 4.36 2020