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10.1038/s41577-020-0311-8 http://scihub22266oqcxt.onion/10.1038/s41577-020-0311-8 32346093!7187672!32346093     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Immunol 2020 ; 20 (6): 363-374 Nephropedia Template TP {{tp|p=32346093|t=2020. The trinity of COVID-19: immunity, inflammation and intervention |pdf=|usr=}}{{32346093}} gab.com Text The trinity of COVID-19: immunity, inflammation and intervention JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32346093 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies. Here, we provide an overview of the pathophysiology of SARS-CoV-2 infection. We describe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression. From nascent reports describing SARS-CoV-2, we make inferences on the basis of the parallel pathophysiological and immunological features of the other human coronaviruses targeting the lower respiratory tract - severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Finally, we highlight the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation. Twit Text FOAVip The trinity of COVID-19: immunity, inflammation and intervention ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32346093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32346093 #FOAvip English Wikipedia <ref>{{Cite pmid|32346093}}</ref> The trinity of COVID-19: immunity, inflammation and intervention #MMPMID32346093 Tay MZ; Poh CM; Renia L; MacAry PA; Ng LFP Nat Rev Immunol 2020[Jun]; 20 (6): 363-374 PMID32346093show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies. Here, we provide an overview of the pathophysiology of SARS-CoV-2 infection. We describe the interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression. From nascent reports describing SARS-CoV-2, we make inferences on the basis of the parallel pathophysiological and immunological features of the other human coronaviruses targeting the lower respiratory tract - severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Finally, we highlight the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation. |*Coronavirus Infections/immunology/physiopathology/therapy/virology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/immunology/physiopathology/therapy/virology[MESH] |Animals[MESH] |Betacoronavirus/immunology/physiology[MESH] |COVID-19[MESH] |Disease Progression[MESH] |Humans[MESH] |Inflammation/etiology/immunology[MESH]The trinity of COVID-19: immunity, inflammation and intervention (epmc).pdf DeepDyve Pubget Overpricing