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10.4187/respcare.07882 http://scihub22266oqcxt.onion/10.4187/respcare.07882 32345741!ä!32345741 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respir+Care 2020 ; 65 (7): 920-931 Nephropedia Template TP {{tp|p=32345741|t=2020. Multiplex Ventilation: A Simulation-Based Study of Ventilating 2 Patients With a Single Ventilator |pdf=|usr=}}{{32345741}} gab.com Text Multiplex Ventilation: A Simulation-Based Study of Ventilating 2 Patients With a Single Ventilator JO: Respir Care http://www.kidney.de/pget.php?&tw=1&pmid=32345741 #FOAvip BACKGROUND: The overwhelming demand for mechanical ventilators due to COVID-19 has stimulated interest in using one ventilator for multiple patients (ie, multiplex ventilation). Despite a plethora of information on the internet, there is little supporting evidence and no human studies. The risk of multiplex ventilation is that ventilation and PEEP effects are largely uncontrollable and depend on the difference between patients' resistance and compliance. It is not clear whether volume control ventilation or pressure control ventilation is safer or more effective. We designed a simulation-based study to allow complete control over the relevant variables to determine the effects of various degrees of resistance-compliance imbalance on tidal volume (V(T)), end-expiratory lung volume (EELV), and imputed pH. METHODS: Two separate breathing simulators were ventilated with a ventilator using pressure control and volume control ventilation modes. Evidence-based lung models simulated a range of differences in resistance and compliance (6 pairs of simulated patients). Differences in V(T), EELV, and imputed pH were recorded. RESULTS: Depending on differences in resistance and compliance, differences in V(T) ranged from 1% (with equal resistance and compliance) to 79%. Differences in EELV ranged from 2% to 109%, whereas differences in pH ranged from 0% to 5%. Failure due to excessive V(T) (ie, > 8 mL/kg) did not occur, but failure due to excessive EELV difference (ie, > 10%) was evident in 50% of patient pairs. There was no difference in failure rate between volume control and pressure control ventilation modes. CONCLUSIONS: These experiments confirmed the potential for markedly different ventilation and oxygenation for patients with uneven respiratory system impedances during multiplex ventilation. Three critical problems must be solved to minimize risk: (1) partitioning of inspiratory flow from the ventilator individually between the 2 patients, (2) measurement of V(T) delivered to each patient, and (3) provision for individual PEEP. We provide suggestions for solving these problems. Twit Text FOAVip Multiplex Ventilation: A Simulation-Based Study of Ventilating 2 Patients With a Single Ventilator ????Respir Care http://www.kidney.de/pget.php?&tw=1&pmid=32345741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32345741 #FOAvip English Wikipedia <ref>{{Cite pmid|32345741}}</ref> Multiplex Ventilation: A Simulation-Based Study of Ventilating 2 Patients With a Single Ventilator #MMPMID32345741 Chatburn RL; Branson RD; Hatipoglu U Respir Care 2020[Jul]; 65 (7): 920-931 PMID32345741show ga BACKGROUND: The overwhelming demand for mechanical ventilators due to COVID-19 has stimulated interest in using one ventilator for multiple patients (ie, multiplex ventilation). Despite a plethora of information on the internet, there is little supporting evidence and no human studies. The risk of multiplex ventilation is that ventilation and PEEP effects are largely uncontrollable and depend on the difference between patients' resistance and compliance. It is not clear whether volume control ventilation or pressure control ventilation is safer or more effective. We designed a simulation-based study to allow complete control over the relevant variables to determine the effects of various degrees of resistance-compliance imbalance on tidal volume (V(T)), end-expiratory lung volume (EELV), and imputed pH. METHODS: Two separate breathing simulators were ventilated with a ventilator using pressure control and volume control ventilation modes. Evidence-based lung models simulated a range of differences in resistance and compliance (6 pairs of simulated patients). Differences in V(T), EELV, and imputed pH were recorded. RESULTS: Depending on differences in resistance and compliance, differences in V(T) ranged from 1% (with equal resistance and compliance) to 79%. Differences in EELV ranged from 2% to 109%, whereas differences in pH ranged from 0% to 5%. Failure due to excessive V(T) (ie, > 8 mL/kg) did not occur, but failure due to excessive EELV difference (ie, > 10%) was evident in 50% of patient pairs. There was no difference in failure rate between volume control and pressure control ventilation modes. CONCLUSIONS: These experiments confirmed the potential for markedly different ventilation and oxygenation for patients with uneven respiratory system impedances during multiplex ventilation. Three critical problems must be solved to minimize risk: (1) partitioning of inspiratory flow from the ventilator individually between the 2 patients, (2) measurement of V(T) delivered to each patient, and (3) provision for individual PEEP. We provide suggestions for solving these problems. |*Coronavirus Infections/epidemiology/therapy[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/epidemiology/therapy[MESH] |*Respiration, Artificial/instrumentation/methods[MESH] |Airway Resistance/*physiology[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Computer Simulation[MESH] |Critical Care/methods[MESH] |Equipment Design[MESH] |Humans[MESH] |Lung Compliance/*physiology[MESH] |Materials Testing/*methods[MESH] |Models, Biological[MESH] |SARS-CoV-2[MESH]Multiplex Ventilation: A Simulation-Based Study of Ventilating 2 Patie(epmc).pdf DeepDyve Pubget Overpricing