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Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection #MMPMID32345328
Kong Q; Xiang Z; Wu Y; Gu Y; Guo J; Geng F
Mol Cancer 2020[Apr]; 19 (1): 80 PMID32345328show ga
Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.
|*Betacoronavirus[MESH]
|Adenocarcinoma of Lung/*complications/genetics[MESH]