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10.1186/s12943-020-01209-2

http://scihub22266oqcxt.onion/10.1186/s12943-020-01209-2
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32345328!7186321!32345328
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suck abstract from ncbi


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pmid32345328      Mol+Cancer 2020 ; 19 (1): 80
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  • Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection #MMPMID32345328
  • Kong Q; Xiang Z; Wu Y; Gu Y; Guo J; Geng F
  • Mol Cancer 2020[Apr]; 19 (1): 80 PMID32345328show ga
  • Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.
  • |*Betacoronavirus[MESH]
  • |Adenocarcinoma of Lung/*complications/genetics[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |COVID-19[MESH]
  • |Carcinoma, Squamous Cell/*complications/genetics[MESH]
  • |Cell Line[MESH]
  • |Coronavirus Infections/*etiology/genetics[MESH]
  • |Disease Susceptibility[MESH]
  • |Gene Expression Profiling[MESH]
  • |Gene Expression Regulation, Neoplastic[MESH]
  • |Humans[MESH]
  • |Lung Neoplasms/*complications/genetics[MESH]
  • |Mice[MESH]
  • |Mice, Transgenic[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/biosynthesis/*genetics[MESH]
  • |Pneumonia, Viral/*etiology/genetics[MESH]
  • |SARS-CoV-2[MESH]


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