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10.1186/s12879-020-05010-w

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32345226!7188494!32345226
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suck abstract from ncbi


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pmid32345226      BMC+Infect+Dis 2020 ; 20 (1): 311
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  • Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study #MMPMID32345226
  • Zhao XY; Xu XX; Yin HS; Hu QM; Xiong T; Tang YY; Yang AY; Yu BP; Huang ZP
  • BMC Infect Dis 2020[Apr]; 20 (1): 311 PMID32345226show ga
  • BACKGROUND: Since December 2019, the 2019 coronavirus disease (COVID-19) has expanded to cause a worldwide outbreak that more than 600,000 people infected and tens of thousands died. To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described. METHODS: We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. RESULTS: Of the 91 patients diagnosed with COVID-19, 30 cases (33.0%) were severe and two patients (2.2%) died. The severe disease group tended to be older (50.5 vs. 42.0 years; p = 0.049) and have more chronic disease (40% vs. 14.8%; p = 0.009) relative to mild disease group. Only 73.6% of the patients were quantitative polymerase chain reaction (qPCR)-positive on their first tests, while typical chest computed tomography images were obtained for each patient. The most common complaints were cough (n = 75; 82.4%), fever (n = 59; 64.8%), fatigue (n = 35; 38.5%), and diarrhea (n = 14; 15.4%). Non-respiratory injury was identified by elevated levels of aspartate aminotransferase (n = 18; 19.8%), creatinine (n = 5; 5.5%), and creatine kinase (n = 14; 15.4%) in laboratory tests. Twenty-eight cases (30.8%) suffered non-respiratory injury, including 50% of the critically ill patients and 21.3% of the mild patients. CONCLUSIONS: Overall, the mortality rate of patients in Jingzhou was lower than that of Wuhan. Importantly, we found liver, kidney, digestive tract, and heart injuries in COVID-19 cases besides respiratory problems. Combining chest computed tomography images with the qPCR analysis of throat swab samples can improve the accuracy of COVID-19 diagnosis.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |COVID-19[MESH]
  • |China/epidemiology[MESH]
  • |Coronavirus Infections/*complications/diagnostic imaging/epidemiology/therapy[MESH]
  • |Cough/etiology[MESH]
  • |Diarrhea/etiology[MESH]
  • |Disease Outbreaks[MESH]
  • |Fatigue/etiology[MESH]
  • |Female[MESH]
  • |Fever/etiology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/diagnostic imaging/epidemiology/therapy[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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