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10.1016/j.jcv.2020.104370

http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104370
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suck abstract from ncbi


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pmid32344321      J+Clin+Virol 2020 ; 127 (ä): 104370
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  • Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19 #MMPMID32344321
  • Liu F; Li L; Xu M; Wu J; Luo D; Zhu Y; Li B; Song X; Zhou X
  • J Clin Virol 2020[Jun]; 127 (ä): 104370 PMID32344321show ga
  • BACKGROUND: The inflammatory response plays a critical role in coronavirus disease 2019 (COVID-19), and inflammatory cytokine storm increases the severity of COVID-19. OBJECTIVE: To investigate the ability of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) to predict mild and severe cases of COVID-19. STUDY DESIGN: This retrospective cohort study included 140 patients diagnosed with COVID-19 from January 18, 2020, to March 12, 2020. The study population was divided into two groups according to disease severity: a mild group (MG) (n = 107) and a severe group (SG) (n = 33). Data on demographic characteristics, baseline clinical characteristics, and the levels of IL-6, CRP, and PCT on admission were collected. RESULTS: Among the 140 patients, the levels of IL-6, CRP, and PCT increased in 95 (67.9 %), 91 (65.0 %), and 8 (5.7 %) patients on admission, respectively. The proportion of patients with increased IL-6, CRP, and PCT levels was significantly higher in the SG than in the MG. Cox proportional hazard model showed that IL-6 and CRP could be used as independent factors to predict the severity of COVID-19. Furthermore, patients with IL-6 > 32.1 pg/mL or CRP > 41.8 mg/L were more likely to have severe complications. CONCLUSION: The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus[MESH]
  • |Biomarkers/blood[MESH]
  • |C-Reactive Protein/*analysis[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*blood/*diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/*diagnosis[MESH]
  • |Procalcitonin/*analysis[MESH]
  • |Prognosis[MESH]
  • |Proportional Hazards Models[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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