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10.1016/j.jcv.2020.104361 http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104361 32344320!7152870!32344320     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Virol 2020 ; 127 (ä): 104361 Nephropedia Template TP {{tp|p=32344320|t=2020. The clinical course and its correlated immune status in COVID-19 pneumonia |pdf=|usr=}}{{32344320}} gab.com Text The clinical course and its correlated immune status in COVID-19 pneumonia JO: J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=32344320 #FOAvip OBJECTIVES: To explore the clinical course and its dynamic features of immune status in COVID-19 patients and find predictors correlated with severity and prognosis of COVID-19. METHODS: The electronic medical records of 204 patients with COVID-19 pneumonia confirmed by nucleic acid testing were retrospectively collected and analyzed. RESULTS: All patients were divided into severe (69) and non-severe group (135). Lymphocyte subsets count, including CD3(+) T cell, CD4(+) T cell, CD8(+) T cell, B cell (CD19(+)) and NK cell (CD16(+) 56(+)), were significantly lower in severe group (P?0.001). The dynamic levels of T lymphocyte in severe group were significantly lower from disease onset, but in the improved subgroup the value of T lymphocyte began to increase after about 15-day treatment and finally returned to the normal level. The cut-off value of the counts of CD3(+) (576), CD4(+) (391) and CD8(+) (214) T cell were calculated and indicated significantly high sensitivity and specificity for severity of COVID-19. CONCLUSION: Our results shown that the decrease of CD3(+), CD4(+) and CD8(+) T lymphocyte correlated with the course of patients with COVID-19 pneumonia, especially in severe cases. The level of T lymphocyte could be used as an indicator for prediction of severity and prognosis of patients with COVID-19 pneumonia. The application of glucocorticoid should be cautious in severe cases. Twit Text FOAVip The clinical course and its correlated immune status in COVID-19 pneumonia ????J Clin Virol http://www.kidney.de/pget.php?&tw=1&pmid=32344320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32344320 #FOAvip English Wikipedia <ref>{{Cite pmid|32344320}}</ref> The clinical course and its correlated immune status in COVID-19 pneumonia #MMPMID32344320 He R; Lu Z; Zhang L; Fan T; Xiong R; Shen X; Feng H; Meng H; Lin W; Jiang W; Geng Q J Clin Virol 2020[Jun]; 127 (ä): 104361 PMID32344320show ga OBJECTIVES: To explore the clinical course and its dynamic features of immune status in COVID-19 patients and find predictors correlated with severity and prognosis of COVID-19. METHODS: The electronic medical records of 204 patients with COVID-19 pneumonia confirmed by nucleic acid testing were retrospectively collected and analyzed. RESULTS: All patients were divided into severe (69) and non-severe group (135). Lymphocyte subsets count, including CD3(+) T cell, CD4(+) T cell, CD8(+) T cell, B cell (CD19(+)) and NK cell (CD16(+) 56(+)), were significantly lower in severe group (P?0.001). The dynamic levels of T lymphocyte in severe group were significantly lower from disease onset, but in the improved subgroup the value of T lymphocyte began to increase after about 15-day treatment and finally returned to the normal level. The cut-off value of the counts of CD3(+) (576), CD4(+) (391) and CD8(+) (214) T cell were calculated and indicated significantly high sensitivity and specificity for severity of COVID-19. CONCLUSION: Our results shown that the decrease of CD3(+), CD4(+) and CD8(+) T lymphocyte correlated with the course of patients with COVID-19 pneumonia, especially in severe cases. The level of T lymphocyte could be used as an indicator for prediction of severity and prognosis of patients with COVID-19 pneumonia. The application of glucocorticoid should be cautious in severe cases. |Adult[MESH] |Aged[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/*immunology[MESH] |Electronic Health Records[MESH] |Female[MESH] |Humans[MESH] |Lymphocyte Count[MESH] |Lymphocyte Subsets/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/*immunology[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH]The clinical course and its correlated immune status in COVID-19 pneum(epmc).pdf DeepDyve Pubget Overpricing