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10.1016/j.ebiom.2020.102768 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2020.102768 32344202!7161485!32344202     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2020 ; 55 (ä): 102768 Nephropedia Template TP {{tp|p=32344202|t=2020. Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development |pdf=|usr=}}{{32344202}} gab.com Text Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32344202 #FOAvip The pandemic spread of a novel coronavirus - SARS coronavirus-2 (SARS-CoV-2) as a cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of many countries under unprecedented stress. Global economies are also spiraling towards a recession in fear of this new life-threatening disease. Vaccines that prevent SARS-CoV-2 infection and therapeutics that reduces the risk of severe Covid-19 are thus urgently needed. A rapid method to derive antiviral treatment for Covid-19 is the use of convalescent plasma derived hyperimmune globulin. However, both hyperimmune globulin and vaccine development face a common hurdle - the risk of antibody-mediated disease enhancement. The goal of this review is to examine the body of evidence supporting the hypothesis of immune enhancement that could be pertinent to Covid-19. We also discuss how this risk could be mitigated so that both hyperimmune globulin and vaccines could be rapidly translated to overcome the current global health crisis. Twit Text FOAVip Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32344202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32344202 #FOAvip English Wikipedia <ref>{{Cite pmid|32344202}}</ref> Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development #MMPMID32344202 de Alwis R; Chen S; Gan ES; Ooi EE EBioMedicine 2020[May]; 55 (ä): 102768 PMID32344202show ga The pandemic spread of a novel coronavirus - SARS coronavirus-2 (SARS-CoV-2) as a cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of many countries under unprecedented stress. Global economies are also spiraling towards a recession in fear of this new life-threatening disease. Vaccines that prevent SARS-CoV-2 infection and therapeutics that reduces the risk of severe Covid-19 are thus urgently needed. A rapid method to derive antiviral treatment for Covid-19 is the use of convalescent plasma derived hyperimmune globulin. However, both hyperimmune globulin and vaccine development face a common hurdle - the risk of antibody-mediated disease enhancement. The goal of this review is to examine the body of evidence supporting the hypothesis of immune enhancement that could be pertinent to Covid-19. We also discuss how this risk could be mitigated so that both hyperimmune globulin and vaccines could be rapidly translated to overcome the current global health crisis. |*Pandemics/prevention & control[MESH] |*Virus Internalization[MESH] |Animals[MESH] |Antibodies, Viral/*adverse effects/immunology[MESH] |COVID-19[MESH] |COVID-19 Serotherapy[MESH] |COVID-19 Vaccines[MESH] |Clinical Trials, Phase I as Topic[MESH] |Convalescence[MESH] |Coronavirus Infections/epidemiology/*immunology/prevention & control/therapy[MESH] |Dendritic Cells/virology[MESH] |Global Health[MESH] |Host Microbial Interactions/immunology[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Macrophages/virology[MESH] |Models, Animal[MESH] |Monocytes/virology[MESH] |Plasma[MESH] |Plasmapheresis[MESH] |Pneumonia, Viral/epidemiology/*immunology/prevention & control/therapy[MESH] |Receptors, Fc/immunology[MESH] |Translational Research, Biomedical[MESH]Impact of immune enhancement on Covid-19 polyclonal hyperimmune globul(epmc).pdf DeepDyve Pubget Overpricing