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10.1016/j.jaci.2020.04.021

http://scihub22266oqcxt.onion/10.1016/j.jaci.2020.04.021
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32344056!7194727!32344056
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  • Eosinophil responses during COVID-19 infections and coronavirus vaccination #MMPMID32344056
  • Lindsley AW; Schwartz JT; Rothenberg ME
  • J Allergy Clin Immunol 2020[Jul]; 146 (1): 1-7 PMID32344056show ga
  • Eosinophils are circulating and tissue-resident leukocytes that have potent proinflammatory effects in a number of diseases. Recently, eosinophils have been shown to have various other functions, including immunoregulation and antiviral activity. Eosinophil levels vary dramatically in a number of clinical settings, especially following eosinophil-targeted therapy, which is now available to selectively deplete these cells. There are key coronavirus disease 2019 (COVID-19)-related questions concerning eosinophils whose answers affect recommended prevention and care. First, do patients with eosinophilia-associated diseases have an altered course of COVID-19? Second, do patients with eosinopenia (now intentionally induced by biological drugs) have unique COVID-19 susceptibility and/or disease course? This is a particularly relevant question because eosinopenia is associated with acute respiratory deterioration during infection with the severe acute respiratory syndrome coronavirus 2, the causative agent of COVID-19. Third, do eosinophils contribute to the lung pathology induced during COVID-19 and will they contribute to immunopotentiation potentially associated with emerging COVID-19 vaccines? Herein, we address these timely questions and project considerations during the emerging COVID-19 pandemic.
  • |Animals[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |Coronavirus Infections/*immunology/*prevention & control[MESH]
  • |Eosinophils/*immunology[MESH]
  • |Humans[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/*immunology/*prevention & control[MESH]
  • |Viral Vaccines/*immunology[MESH]


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  • suck abstract from ncbi

    1 1.146 2020