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10.1002/jmv.25946

http://scihub22266oqcxt.onion/10.1002/jmv.25946
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32343415!7267623!32343415
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suck abstract from ncbi


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pmid32343415      J+Med+Virol 2020 ; 92 (9): 1684-1689
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  • Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients #MMPMID32343415
  • Wang B; Wang L; Kong X; Geng J; Xiao D; Ma C; Jiang XM; Wang PH
  • J Med Virol 2020[Sep]; 92 (9): 1684-1689 PMID32343415show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has spread worldwide. Whether antibodies are important for the adaptive immune responses against SARS-CoV-2 infection needs to be determined. Here, 26 cases of COVID-19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms, and no case of severe symptoms was found among these patients. Strikingly, a subset of these patients had SARS-CoV-2 and virus-specific IgG coexist for an unexpectedly long time, with two cases for up to 50 days. One COVID-19 patient who did not produce any SARS-CoV-2-bound IgG successfully cleared SARS-CoV-2 after 46 days of illness, revealing that without antibody-mediated adaptive immunity, innate immunity alone may still be powerful enough to eliminate SARS-CoV-2. This report may provide a basis for further analysis of both innate and adaptive immunity in SARS-CoV-2 clearance, especially in nonsevere cases.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/blood/*immunology[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/blood/*immunology/*virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Host-Pathogen Interactions/*immunology[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Immunoglobulin G/blood/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Viral Load[MESH]


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