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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Environ+Microbiol 2020 ; 22 (6): 1997-2000 Nephropedia Template TP
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The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19 #MMPMID32342578
Armengaud J; Delaunay-Moisan A; Thuret JY; van Anken E; Acosta-Alvear D; Aragon T; Arias C; Blondel M; Braakman I; Collet JF; Courcol R; Danchin A; Deleuze JF; Lavigne JP; Lucas S; Michiels T; Moore ERB; Nixon-Abell J; Rossello-Mora R; Shi ZL; Siccardi AG; Sitia R; Tillett D; Timmis KN; Toledano MB; van der Sluijs P; Vicenzi E
Environ Microbiol 2020[Jun]; 22 (6): 1997-2000 PMID32342578show ga
The current SARS-CoV-2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID-19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS-CoV-2 would offer significant relief, although vaccine developers have warned that design, testing and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (i), but the earliest vaccines were based on the live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (ii). What makes the current pandemic unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in detail how SARS-CoV-2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS-CoV-2 variants across the globe should be of key interest in our fight against the pandemic.