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10.3934/Neuroscience.2019.4.219 http://scihub22266oqcxt.onion/10.3934/Neuroscience.2019.4.219 32341978/?report=reader!7179357!32341978     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AIMS+Neurosci 2019 ; 6 (4): 219-230 Nephropedia Template TP {{tp|p=32341978|t=2019. The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics |pdf=|usr=}}{{32341978}} gab.com Text The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics JO: AIMS Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=32341978 #FOAvip In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options. Twit Text FOAVip The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics ????AIMS Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=32341978 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32341978 #FOAvip English Wikipedia <ref>{{Cite pmid|32341978}}</ref> The pedunculopontine nucleus: From posture and locomotion to neuroepigenetics #MMPMID32341978 Virmani T; Urbano FJ; Bisagno V; Garcia-Rill E AIMS Neurosci 2019[]; 6 (4): 219-230 PMID32341978show ga In this review, we discuss first an example of one of the symptoms of PD, freezing of gait (FOG), then we will turn to the use of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) to treat PD, and the original studies that led to identification of the PPN as one source of locomotor control and why stimulation frequency is critical, and then describe the intrinsic properties of PPN neurons that require beta/gamma stimulation in order to fully activate all types of PPN neurons. Finally, we will describe recent findings on the proteomic and molecular consequences of gamma band activity in PPN neurons, with emphasis on the potential neuroepigenetic sequelae. These considerations will provide essential information for the appropriate refining and testing of PPN DBS as a potential therapy for PD, as well as alternative options. äThe pedunculopontine nucleus: From posture and locomotion to neuroepig(epmc).pdf DeepDyve Pubget Overpricing