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10.1016/j.it.2020.04.001

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suck abstract from ncbi


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pmid32340868      Trends+Immunol 2020 ; 41 (6): 457-465
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  • Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome? #MMPMID32340868
  • Tsang JS; Dobano C; VanDamme P; Moncunill G; Marchant A; Othman RB; Sadarangani M; Koff WC; Kollmann TR
  • Trends Immunol 2020[Jun]; 41 (6): 457-465 PMID32340868show ga
  • Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies ('precision vaccination'). If baseline immune signatures are predictive, the underlying mechanism they reflect may also determine vaccination outcome. Thus, baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses. This concept has the potential to transform vaccination strategies and usher in a new approach to improve global health.
  • |*Immunity, Active/immunology[MESH]
  • |*Vaccines/immunology[MESH]
  • |Humans[MESH]


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