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10.1093/dnares/dsaa008 http://scihub22266oqcxt.onion/10.1093/dnares/dsaa008 32339222!7320823!32339222     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       DNA+Res 2020 ; 27 (2): ä Nephropedia Template TP {{tp|p=32339222|t=2020. Evolutionary selection against short nucleotide sequences in viruses and their related hosts |pdf=|usr=}}{{32339222}} gab.com Text Evolutionary selection against short nucleotide sequences in viruses and their related hosts JO: DNA Res http://www.kidney.de/pget.php?&tw=1&pmid=32339222 #FOAvip Viruses are under constant evolutionary pressure to effectively interact with the host intracellular factors, while evading its immune system. Understanding how viruses co-evolve with their hosts is a fundamental topic in molecular evolution and may also aid in developing novel viral based applications such as vaccines, oncologic therapies, and anti-bacterial treatments. Here, based on a novel statistical framework and a large-scale genomic analysis of 2,625 viruses from all classes infecting 439 host organisms from all kingdoms of life, we identify short nucleotide sequences that are under-represented in the coding regions of viruses and their hosts. These sequences cannot be explained by the coding regions' amino acid content, codon, and dinucleotide frequencies. We specifically show that short homooligonucleotide and palindromic sequences tend to be under-represented in many viruses probably due to their effect on gene expression regulation and the interaction with the host immune system. In addition, we show that more sequences tend to be under-represented in dsDNA viruses than in other viral groups. Finally, we demonstrate, based on in vitro and in vivo experiments, how under-represented sequences can be used to attenuated Zika virus strains. Twit Text FOAVip Evolutionary selection against short nucleotide sequences in viruses and their related hosts ????DNA Res http://www.kidney.de/pget.php?&tw=1&pmid=32339222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32339222 #FOAvip English Wikipedia <ref>{{Cite pmid|32339222}}</ref> Evolutionary selection against short nucleotide sequences in viruses and their related hosts #MMPMID32339222 Zarai Y; Zafrir Z; Siridechadilok B; Suphatrakul A; Roopin M; Julander J; Tuller T DNA Res 2020[Apr]; 27 (2): ä PMID32339222show ga Viruses are under constant evolutionary pressure to effectively interact with the host intracellular factors, while evading its immune system. Understanding how viruses co-evolve with their hosts is a fundamental topic in molecular evolution and may also aid in developing novel viral based applications such as vaccines, oncologic therapies, and anti-bacterial treatments. Here, based on a novel statistical framework and a large-scale genomic analysis of 2,625 viruses from all classes infecting 439 host organisms from all kingdoms of life, we identify short nucleotide sequences that are under-represented in the coding regions of viruses and their hosts. These sequences cannot be explained by the coding regions' amino acid content, codon, and dinucleotide frequencies. We specifically show that short homooligonucleotide and palindromic sequences tend to be under-represented in many viruses probably due to their effect on gene expression regulation and the interaction with the host immune system. In addition, we show that more sequences tend to be under-represented in dsDNA viruses than in other viral groups. Finally, we demonstrate, based on in vitro and in vivo experiments, how under-represented sequences can be used to attenuated Zika virus strains. |*Biological Coevolution[MESH] |*Evolution, Molecular[MESH] |*Genome, Viral[MESH] |*Nucleotide Motifs[MESH] |*Selection, Genetic[MESH] |Animals[MESH] |Bacteria/genetics/virology[MESH] |Female[MESH] |Fungi/genetics/virology[MESH] |Host-Pathogen Interactions[MESH] |Male[MESH] |Mice[MESH] |Oligonucleotides/genetics[MESH] |Plants/genetics/virology[MESH] |Systems Biology/methods[MESH]Evolutionary selection against short nucleotide sequences in viruses a(epmc).pdf DeepDyve Pubget Overpricing