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10.7554/eLife.57555 http://scihub22266oqcxt.onion/10.7554/eLife.57555 32338605!7213974!32338605     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32338605&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=32338605|t=2020. Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome |pdf=|usr=}}{{32338605}} gab.com Text Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=32338605 #FOAvip COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to inactivate des-Arg9 bradykinin, the potent ligand of the B1R. Without ACE2 acting as a guardian to inactivate the ligands of B1R, the lung environment is prone for local vascular leakage leading to angioedema. Here, we hypothesize that a kinin-dependent local lung angioedema via B1R and eventually B2R is an important feature of COVID-19. We propose that blocking the B2R and inhibiting plasma kallikrein activity might have an ameliorating effect on early disease caused by COVID-19 and might prevent acute respiratory distress syndrome (ARDS). In addition, this pathway might indirectly be responsive to anti-inflammatory agents. Twit Text FOAVip Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=32338605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32338605 #FOAvip English Wikipedia <ref>{{Cite pmid|32338605}}</ref> Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome #MMPMID32338605 van de Veerdonk FL; Netea MG; van Deuren M; van der Meer JW; de Mast Q; Bruggemann RJ; van der Hoeven H Elife 2020[Apr]; 9 (ä): ä PMID32338605show ga COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to inactivate des-Arg9 bradykinin, the potent ligand of the B1R. Without ACE2 acting as a guardian to inactivate the ligands of B1R, the lung environment is prone for local vascular leakage leading to angioedema. Here, we hypothesize that a kinin-dependent local lung angioedema via B1R and eventually B2R is an important feature of COVID-19. We propose that blocking the B2R and inhibiting plasma kallikrein activity might have an ameliorating effect on early disease caused by COVID-19 and might prevent acute respiratory distress syndrome (ARDS). In addition, this pathway might indirectly be responsive to anti-inflammatory agents. |*Drug Development[MESH] |Angioedema/drug therapy/metabolism/pathology[MESH] |Anti-Inflammatory Agents/therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |Betacoronavirus/physiology[MESH] |Bradykinin Receptor Antagonists/therapeutic use[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/metabolism/*pathology[MESH] |Endothelial Cells/metabolism/pathology[MESH] |Humans[MESH] |Inflammation/immunology/pathology[MESH] |Kallikreins/metabolism[MESH] |Kinins/metabolism[MESH] |Lung/metabolism/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/metabolism/*pathology[MESH] |Receptor, Bradykinin B1/metabolism[MESH] |Receptor, Bradykinin B2/metabolism[MESH] |Respiratory Distress Syndrome/drug therapy/pathology/prevention & control[MESH] |SARS-CoV-2[MESH]Kallikrein-kinin blockade in patients with COVID-19 to prevent acute r(epmc).pdf DeepDyve Pubget Overpricing